Gomisin A

CAS NO.：58546-54-6
Empirical Formula: C23H28O7
Molecular Weight: 416.47
MDL number: MFCD01941645
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is Gomisin A?

Description

Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity. It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells. It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen .

Chemical properties

White powder

The Uses of Gomisin A

Schizandrol B exhibits potent protective effects of on ET-1-induced dysfunctional human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). Anti-cholestasis effect.

Properties of Gomisin A

Melting point:	88.5°C
Boiling point:	454.79°C (rough estimate)
Density	1.1772 (rough estimate)
refractive index	1.5300 (estimate)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO : 50 mg/mL (120.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form	powder to crystal
pka	14.58±0.40(Predicted)
color	White to Light yellow

Safety information for Gomisin A

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product.