GLYCOFUROL
- CAS NO.:31692-85-0
- Empirical Formula: C11H21O5R
- Molecular Weight: 233.28
- MDL number: MFCD00801146
- EINECS: 608-659-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-15 19:00:21
What is GLYCOFUROL?
Chemical properties
Glycofurol is a clear, colorless, almost odorless liquid, with a bitter taste; it produces a warm sensation on the tongue.
The Uses of GLYCOFUROL
Glycofurol is used as a carrier device for drug delivery.
The Uses of GLYCOFUROL
Used as solvent to dissolve water-insoluble compounds.
What are the applications of Application
Tetraglycol is a solvent used to dissolve water-insoluble compounds
Production Methods
Glycofurol is prepared by the reaction of tetrahydrofurfuryl alcohol with ethylene oxide (followed by a special purification process in the case of Glycofurol 75).
Pharmaceutical Applications
Glycofurol is used as a solvent in parenteral products for intravenous or intramuscular injection in concentrations up to 50% v/v. It has also been investigated, mainly in animal studies, for use as a penetration enhancer and solvent in topical and intranasal formulations. Glycofurol has also been used at 20% v/v concentration in a rectal formulation.
Safety
Glycofurol is mainly used as a solvent in parenteral pharmaceutical
formulations and is generally regarded as a relatively nontoxic and
nonirritant material at the levels used as a pharmaceutical excipient.
Glycofurol can be irritant when used undiluted; its tolerability is
approximately the same as propylene glycol.
Glycofurol may have an effect on liver function and may have a
low potential for interaction with hepatoxins or those materials
undergong extensive hepatic metabolism.
LD50 (mouse, IV): 3.5 mL/kg
storage
Stable if stored under nitrogen in a well-closed container protected from light, in a cool, dry place.
Incompatibilities
Incompatible with oxidizing agents.
Regulatory Status
Included in parenteral medicines licensed in Europe.
Properties of GLYCOFUROL
Boiling point: | 100-145 °C0.4 mm Hg |
Density | 1.09 g/mL at 25 °C(lit.) |
vapor pressure | 4.97-37.4Pa at 20-50℃ |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Store below +30°C. |
solubility | Chloroform (Sparingly), Methanol (Slightly, Sonicated) |
form | Oil |
color | Colourless |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
Safety information for GLYCOFUROL
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for GLYCOFUROL
Abamectin manufacturer
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