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HomeProduct name listGLYCOFUROL

GLYCOFUROL

  • CAS NO.:31692-85-0
  • Empirical Formula: C11H21O5R
  • Molecular Weight: 233.28
  • MDL number: MFCD00801146
  • EINECS: 608-659-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-15 19:00:21
GLYCOFUROL Structural

What is GLYCOFUROL?

Chemical properties

Glycofurol is a clear, colorless, almost odorless liquid, with a bitter taste; it produces a warm sensation on the tongue.

The Uses of GLYCOFUROL

Glycofurol is used as a carrier device for drug delivery.

The Uses of GLYCOFUROL

Used as solvent to dissolve water-insoluble compounds.

What are the applications of Application

Tetraglycol is a solvent used to dissolve water-insoluble compounds

Production Methods

Glycofurol is prepared by the reaction of tetrahydrofurfuryl alcohol with ethylene oxide (followed by a special purification process in the case of Glycofurol 75).

Pharmaceutical Applications

Glycofurol is used as a solvent in parenteral products for intravenous or intramuscular injection in concentrations up to 50% v/v. It has also been investigated, mainly in animal studies, for use as a penetration enhancer and solvent in topical and intranasal formulations. Glycofurol has also been used at 20% v/v concentration in a rectal formulation.

Safety

Glycofurol is mainly used as a solvent in parenteral pharmaceutical formulations and is generally regarded as a relatively nontoxic and nonirritant material at the levels used as a pharmaceutical excipient. Glycofurol can be irritant when used undiluted; its tolerability is approximately the same as propylene glycol.
Glycofurol may have an effect on liver function and may have a low potential for interaction with hepatoxins or those materials undergong extensive hepatic metabolism.
LD50 (mouse, IV): 3.5 mL/kg

storage

Stable if stored under nitrogen in a well-closed container protected from light, in a cool, dry place.

Incompatibilities

Incompatible with oxidizing agents.

Regulatory Status

Included in parenteral medicines licensed in Europe.

Properties of GLYCOFUROL

Boiling point: 100-145 °C0.4 mm Hg
Density  1.09 g/mL at 25 °C(lit.)
vapor pressure  4.97-37.4Pa at 20-50℃
refractive index  n20/D 1.462(lit.)
Flash point: >230 °F
storage temp.  Store below +30°C.
solubility  Chloroform (Sparingly), Methanol (Slightly, Sonicated)
form  Oil
color  Colourless
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.

Safety information for GLYCOFUROL

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for GLYCOFUROL

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