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HomeProduct name listNIGERICIN SODIUM SALT

NIGERICIN SODIUM SALT

NIGERICIN SODIUM SALT Structural

What is NIGERICIN SODIUM SALT?

The Uses of NIGERICIN SODIUM SALT

Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumour cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication.

Definition

ChEBI: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.

Properties of NIGERICIN SODIUM SALT

Melting point: 183.5-185°
Boiling point: 779.9±60.0 °C(Predicted)
alpha  D24 +36.2° (c = 0.842 in CHCl3)
Density  1.19±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  chloroform: 10 mg/mL, clear, colorless
pka 4.39±0.10(Predicted)

Safety information for NIGERICIN SODIUM SALT

Computed Descriptors for NIGERICIN SODIUM SALT

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