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HomeProduct name listMonensin sodium salt

Monensin sodium salt

Synonym(s):Monensin A sodium salt;Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem

  • CAS NO.:22373-78-0
  • Empirical Formula: C36H63NaO12
  • Molecular Weight: 710.87
  • MDL number: MFCD00077826
  • EINECS: 244-941-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Monensin sodium salt Structural

What is Monensin sodium salt?

Description

Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.

Chemical properties

LIGHT CREAM AMORPHOUS POWDER

The Uses of Monensin sodium salt

Monensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.

The Uses of Monensin sodium salt

Poliether antibiotic. Coccidiostat.

The Uses of Monensin sodium salt

antifungal

The Uses of Monensin sodium salt

antibacterial

What are the applications of Application

Monensin Sodium Salt is a monovalent cation ionophore and transporter

General Description

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis?in poultry production.

Biochem/physiol Actions

Na+ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

storage

-20°C

Purification Methods

Crystallise it from EtOH/H2O [Cox et al. J Am Chem Soc 107 4297 1985].

References

Aowicki and Huczynski (2013), Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements; Res. Int. 2013 742149 Kallen et al. (1993), Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: evidence for two sites of sphingomyelin synthesis in BHK cells; Biophys. Acta 1166 305 Boss et al. (1984), Monensin-induced swelling of Golgi apparatus cisternae mediated by a proton gradient; J. Cell. Biol. 34 1 Mollenhauer et al. (1990), Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity; Biophys. Acta 1031 225 Hafner et al. (2021), The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells; Pharmacol. 12 611657 Oh-Hashi et al. (2021), Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells; J. Mol. Sci. 22 2767

Properties of Monensin sodium salt

Melting point: 267-269 C
alpha  57.3 º (c=4.0, in MeOH)
storage temp.  2-8°C
solubility  Soluble in methanol at 50mg/ml
form  Off-white to beige solid
color  White
BRN  4122200
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
EPA Substance Registry System Monensin, monosodium salt (22373-78-0)

Safety information for Monensin sodium salt

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
ghs
Environment
GHS09
GHS Hazard Statements H300:Acute toxicity,oral
H319:Serious eye damage/eye irritation
H334:Sensitisation, respiratory
H373:Specific target organ toxicity, repeated exposure
H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P273:Avoid release to the environment.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Monensin sodium salt

InChIKey XOIQMTLWECTKJL-BEMBKCOJSA-M

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