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HomeProduct name listGinsenoside Rg2

Ginsenoside Rg2

Synonym(s):(3β,6α,12β)-3,12,20-Trihydroxydammar-24-en-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside;Chikusetsusaponin I;Panaxoside Rg2;Prosapogenin C2

Ginsenoside Rg2 Structural

What is Ginsenoside Rg2?

Description

Ginsenosides are pharmacologically active natural compounds from ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg2 is a protopanaxatriol that is more abundant in some Panax species (e.g., white and red P. ginseng) than others. This ginsenoside and its metabolites have diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-diabetic actions. It also protects against DNA damage and apoptosis induced by ultraviolet light. Notably, this ginsenoside is increased by the metabolism of other bioactive ginsenosides during the steaming or heating of plant materials, particularly in P. quinquefolium.

Chemical properties

White solid

The Uses of Ginsenoside Rg2

20(S)-Ginsenoside Rg2 is used as an aldose reductase inhibitor and my exert anti-inflammatory and immunomodulatory activity. It exists as a bioactive metabolite of the ginsenoside component of Panax ginseng.

What are the applications of Application

Ginsenoside Rg2 is an antiproliferative agent

Definition

ChEBI: Ginsenoside Rg2 is a ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite, a cardioprotective agent and an anticoagulant. It is a beta-D-glucoside, a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a ginsenoside, a tetracyclic triterpenoid, a disaccharide derivative, a 20-hydroxy steroid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.

Properties of Ginsenoside Rg2

Melting point: 187~189℃
Boiling point: 881.0±65.0 °C(Predicted)
Density  1.30±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Methanol (Slightly, Heated, Sonicated), Pyridine (Slightly, Sonicated)
form  Solid
pka 12.85±0.70(Predicted)
color  White to Off-White
Stability: Hygroscopic

Safety information for Ginsenoside Rg2

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for Ginsenoside Rg2

InChIKey AGBCLJAHARWNLA-DJZXLMSJSA-N

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