Geldanamycin-FITC
- CAS NO.:2969156-01-0
- Molecular Weight: 0
- Update Date: 2023-04-23 13:52:06
What is Geldanamycin-FITC?
Description
Geldanamycin-FITC is a novel geldanamycin fluorescent probe1?that may be used in a fluorescence polarization assay for HSP-90 inhibitors.2,3?May also be used for detection of cell surface HSP-90 and for other applications. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of?in vitro?pharmacology to cellular and?in vivo?efficacy.4
The Uses of Geldanamycin-FITC
Geldanamycin-FITC is a novel geldanamycin fluorescent probe. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of in vitro pharmacology to cellular and in vivo efficacy.
References
1) Llauger-Bufi?et al. (2003),?Synthesis of novel fluorescent probes for the molecular chaperone Hsp90;? Bioorg. Med. Chem. Lett.,?13?3975 2) Kim?et al. (2004),?Development of a fluorescent polarization assay for the molecular chaperone Hsp90;? J. Biomol. Screen.,?9?375 3) Austin?et al. (2012),?Fragment screening using capillary electrophoresis (Defrag) for hit identification of heat shock protein 90 ATPase inhibitors;? J. Biomol. Screen.,?17?868 4) Gooljarsingh?et al. (2006),?A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues;? Proc. Natl. Acad. Sci. USA,?103?7625
Properties of Geldanamycin-FITC
storage temp. | -20°C (des.) |
solubility | Soluble in DMSO (greater than 10 mg/ml) |
form | solid |
color | Purple |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Safety information for Geldanamycin-FITC
Computed Descriptors for Geldanamycin-FITC
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