Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listFosfomycin tromethamine

Fosfomycin tromethamine

Synonym(s):Fosfomycin trometamol

  • CAS NO.:78964-85-9
  • Empirical Formula: C7H18NO7P
  • Molecular Weight: 259.19
  • MDL number: MFCD01706261
  • EINECS: 279-018-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-06 15:28:12
Fosfomycin tromethamine Structural

What is Fosfomycin tromethamine?

Chemical properties

White to off-white powder

The Uses of Fosfomycin tromethamine

Fosfomycin Tromethamine is used as an antibiotic compound in the treatment of urinary tract infections.

The Uses of Fosfomycin tromethamine

Phosphonic acid derivative; antibacterial.

Definition

ChEBI: Fosfomycin tromethamine is a phosphonoacetic acid.

brand name

Monurol (Zambon).

General Description

Fosfomycin tromethamine (Monurol) is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.
Fosfomycin is a broad-spectrum, bactericidal antibacterialthat inhibits the growth of E. coli, S. aureus, andSerratia, Klebsiella, Citrobacter, Enterococcus, andEnterobacter spp. at a concentration less than 64 mg/L.Currently fosfomycin is recommended as single-dose therapyfor uncomplicated urinary tract infections. It possessesin vitro efficacy similar to that of norfloxacin and trimethoprim-sulfamethoxazole.
Fosfomycin covalently inactivates the first enzyme in thebacterial cell wall biosynthesis pathway, UDP-N-acetylglucosamineenolpyruvyl transferase (MurA) by alkylation ofthe cysteine-115 residue. The inactivation reaction occursthrough nucleophilic opening of the epoxide ring. Resistanceto fosfomycin can occur through chromosomal mutationsthat result in reduced uptake or reduced MurA affinity for theinhibitor. Plasmid-mediated resistance mechanisms involveconjugative bioinactivation of the antibiotic with glutathione.The frequency of resistant mutants in in vitro studies hasbeen low, and there appears to be little cross-resistance betweenfosfomycin and other antibacterials.

Properties of Fosfomycin tromethamine

Melting point: 122-125oC
storage temp.  Hygroscopic, Refrigerator, under inert atmosphere
solubility  Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.
form  Solid
color  White to Off-White
Stability: Hygroscopic

Safety information for Fosfomycin tromethamine

Computed Descriptors for Fosfomycin tromethamine

InChIKey QZJIMDIBFFHQDW-LMLSDSMGSA-N

Abamectin manufacturer

KARPSCHEM LABORATORIES PVT. LTD.

1Y
Phone:+917249203006
Whatsapp: +91 7249203006
product: 78964-85-9 Fosfomycin Tromethamine 2-amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3- methyloxiran-2-yl) phosphonate 96%
Inquiry

Bajaj Healthcare Ltd

1Y
Phone:+91-2266177400
product: 78964-85-9 98%
Inquiry

Molsyns Research

1Y
Phone:+91-9586858886
Whatsapp: +91- 9586858886
product: Fosfomycin Tromethamine 98%
Inquiry

Sumar Biotech LLP

1Y
Phone:+91-9824575381
Whatsapp: +91-9824575381
product: Fosfomycin tromethamine 98%
Inquiry

BDR Pharmaceuticals International Pvt Ltd

1Y
Phone:+917718884418
Whatsapp: +91-7718884418
product: Fosfomycin tromethamine 78964-85-9 98%
Inquiry

Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)

Maharashtra
product: Fosfomycin tromethamine
Inquiry

Related products of tetrahydrofuran

You may like

  • 78964-85-9 Fosfomycin Tromethamine
2-amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3- methyloxiran-2-yl)
phosphonate 96%
    78964-85-9 Fosfomycin Tromethamine 2-amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3- methyloxiran-2-yl) phosphonate 96%
    78964-85-9
    View Details
  • 78964-85-9 98%
    78964-85-9 98%
    78964-85-9
    View Details
  • Fosfomycin tromethamine 98%
    Fosfomycin tromethamine 98%
    78964-85-9
    View Details
  • Fosfomycin tromethamine 78964-85-9 98%
    Fosfomycin tromethamine 78964-85-9 98%
    78964-85-9
    View Details
  • Fosfomycin Tromethamine 98%
    Fosfomycin Tromethamine 98%
    78964-85-9
    View Details
  • Fosfomycin tromethamine 95% CAS 78964-85-9
    Fosfomycin tromethamine 95% CAS 78964-85-9
    78964-85-9
    View Details
  • Fosfomycin tromethamine CAS 78964-85-9
    Fosfomycin tromethamine CAS 78964-85-9
    78964-85-9
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.