Fosfomycin tromethamine
Synonym(s):Fosfomycin trometamol
- CAS NO.:78964-85-9
- Empirical Formula: C7H18NO7P
- Molecular Weight: 259.19
- MDL number: MFCD01706261
- EINECS: 279-018-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is Fosfomycin tromethamine?
Chemical properties
White to off-white powder
The Uses of Fosfomycin tromethamine
Fosfomycin Tromethamine is used as an antibiotic compound in the treatment of urinary tract infections.
The Uses of Fosfomycin tromethamine
Phosphonic acid derivative; antibacterial.
Definition
ChEBI: Fosfomycin tromethamine is a phosphonoacetic acid.
brand name
Monurol (Zambon).
General Description
Fosfomycin tromethamine (Monurol) is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.
Fosfomycin is a broad-spectrum, bactericidal antibacterialthat inhibits the growth of E. coli, S. aureus, andSerratia, Klebsiella, Citrobacter, Enterococcus, andEnterobacter spp. at a concentration less than 64 mg/L.Currently fosfomycin is recommended as single-dose therapyfor uncomplicated urinary tract infections. It possessesin vitro efficacy similar to that of norfloxacin and trimethoprim-sulfamethoxazole.
Fosfomycin covalently inactivates the first enzyme in thebacterial cell wall biosynthesis pathway, UDP-N-acetylglucosamineenolpyruvyl transferase (MurA) by alkylation ofthe cysteine-115 residue. The inactivation reaction occursthrough nucleophilic opening of the epoxide ring. Resistanceto fosfomycin can occur through chromosomal mutationsthat result in reduced uptake or reduced MurA affinity for theinhibitor. Plasmid-mediated resistance mechanisms involveconjugative bioinactivation of the antibiotic with glutathione.The frequency of resistant mutants in in vitro studies hasbeen low, and there appears to be little cross-resistance betweenfosfomycin and other antibacterials.
Properties of Fosfomycin tromethamine
Melting point: | 122-125oC |
storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
solubility | Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone. |
form | Solid |
color | White to Off-White |
Stability: | Hygroscopic |
Safety information for Fosfomycin tromethamine
Computed Descriptors for Fosfomycin tromethamine
InChIKey | QZJIMDIBFFHQDW-LMLSDSMGSA-N |
Abamectin manufacturer
KARPSCHEM LABORATORIES PVT. LTD.
Molsyns Research
Sumar Biotech LLP
BDR Pharmaceuticals International Pvt Ltd
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