FMoc-NH-8(ethylene glycol)-acetic acid
- CAS NO.：868594-52-9
- Empirical Formula: C33H47NO12
- Molecular Weight: 649.73
- MDL number: MFCD27635163
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is FMoc-NH-8(ethylene glycol)-acetic acid?
Description
Fmoc-NH-PEG8-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Properties of FMoc-NH-8(ethylene glycol)-acetic acid
| Boiling point: | 773.7±60.0 °C(Predicted) |
| Density | 1.201±0.06 g/cm3(Predicted) |
| solubility | DMSO : 100 mg/mL (153.91 mM; Need ultrasonic) |
| pka | 3.39±0.10(Predicted) |
| color | Light yellow to brown |
Safety information for FMoc-NH-8(ethylene glycol)-acetic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for FMoc-NH-8(ethylene glycol)-acetic acid
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