Fmoc-9-Amino-4,7-Dioxanonanoic acid
- CAS NO.：872679-70-4
- Empirical Formula: C22H25NO6
- Molecular Weight: 399.44
- MDL number: MFCD08064306
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is Fmoc-9-Amino-4,7-Dioxanonanoic acid?
Description
Fmoc-N-amido-PEG2-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical properties
White crystalline powder
The Uses of Fmoc-9-Amino-4,7-Dioxanonanoic acid
Fmoc-AEEP-OH is used in preparation of glucose-responsive insulin conjugates.
Properties of Fmoc-9-Amino-4,7-Dioxanonanoic acid
| Melting point: | 95.0 to 99.0 °C |
| Boiling point: | 621.0±50.0 °C(Predicted) |
| Density | 1.243±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 2-8°C |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 4.28±0.10(Predicted) |
| color | White to Almost white |
Safety information for Fmoc-9-Amino-4,7-Dioxanonanoic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for Fmoc-9-Amino-4,7-Dioxanonanoic acid
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