Biotin-PEG4-N3
Synonym(s):N-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]hexahydro-2-oxo-(3aS,4S,6aR)- 1H-thieno[3,4-d ]imidazole-4-pentanamide;Biotin-PEG3-azide
- CAS NO.:875770-34-6
- Empirical Formula: C18H32N6O5S
- Molecular Weight: 444.55
- MDL number: MFCD20134145
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is Biotin-PEG4-N3?
Description
Biotin-PEG3-azide is a PEGylated version of biotin-azide that is more hydrophilic due to the incorporation of a PEGylated spacer. It can be used to label terminal alkynes via copper-catalyzed click reactions or copper-free click reactions with cyclooctynes., Biotin-PEG3-azide has been used to non-enzymatically and covalently tag proteins, which can be separated and detected using common laboratory methods such as SDS-PAGE and Western blot. It can be used in combination with other protein tags. Biotin-PEG3-azide has also been used in nanostructured biointerfaces to study ligand and receptor spacing when there are different signaling molecules present.
The Uses of Biotin-PEG4-N3
Biotinylation reagent for labeling alkyne containing molecules or biomolecules using either copper-catalyzed 1,3 dipolar cycloaddition click chemistry or copper-free click chemistry with cyclooctyne derivatives. The azide group reacts with alkynes to form a stable triazole linkage facilitating the introduction of biotin into your alkyne modified system of interest. This reaction is bioorthogonal or in other words compatible with biological systems in that it?s components do not react with the biological environment.
storage
Store at -20°C
Properties of Biotin-PEG4-N3
Melting point: | 107.0 to 112.0 °C |
storage temp. | -20°C |
solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 10 mg/ml |
form | Solid |
color | Off-white to Gray |
Water Solubility | Solubile in DMSO, DMF and water. |
Safety information for Biotin-PEG4-N3
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Biotin-PEG4-N3
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