FEXOFENADINE HYDROCHLORIDE
Synonym(s):Fexofenadine hydrochloride;Fexofenidine hydrochloride;MDL 16455 hydrochloride;Terfenidine carboxylate hydrochloride
- CAS NO.:138452-21-8
- Empirical Formula: C32H40ClNO4
- Molecular Weight: 538.12
- MDL number: MFCD00865710
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:33
What is FEXOFENADINE HYDROCHLORIDE?
Description
The metabolite of seldane (terfenadine), fexofenadine, was launched in the USA. A histamine H1 receptor antagonist, fexofenadine is more effect than its parent compound without the associated side-effects.
Originator
Sepracor (USA)
The Uses of FEXOFENADINE HYDROCHLORIDE
Anti-histamine
The Uses of FEXOFENADINE HYDROCHLORIDE
Fexofenadine HCl (Allegra) is a selective, specific H1 antagonist that is structurally related to the butyrophenone tranquilizer haloperidol. It is the active carboxylic acid metabolite of terfenadine (no longer commercially available in the United States). It binds mainly to the peripheral H1 receptors, with minimal crossing of the blood–brain barrier and hence minimal sedative effects. Fexofenadine lacks the cardiotoxic effects of its parent drug, terfenadine. However, it has been associated with increased QT interval, syncope, and ventricular arrhythmia in at least one susceptible patient with preexisting cardiovascular risk. To date, no significant interactions have been demonstrated with fexofenadine when administered concomitantly with azole antifungals or macrolide antibiotics. Indicated for seasonal allergic rhinitis and chronic idiopathic urticaria.
Definition
ChEBI: Fexofenadine hydrochloride is a diarylmethane.
brand name
Allegra
Dosage forms
60 mg PO b.i.d.
Properties of FEXOFENADINE HYDROCHLORIDE
storage temp. | −20°C |
solubility | DMSO: 32 mg/mL, soluble |
form | solid |
color | white |
Safety information for FEXOFENADINE HYDROCHLORIDE
Computed Descriptors for FEXOFENADINE HYDROCHLORIDE
New Products
Tubulysin A Tubulysin E Tubulysin B 2,2-Difluoropropanol 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 4,4-DIFLUOROPIPERIDINE 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 4,4-DIFLUOROCYCLOHEXANAMINE Imeglimin Hydrochloride IH Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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