Diphenylpiperidin-4-ylmethanol hydrochloride
- CAS NO.:1798-50-1
- Empirical Formula: C18H22ClNO
- Molecular Weight: 303.83
- MDL number: MFCD00039039
- EINECS: 217-284-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 15:13:19
What is Diphenylpiperidin-4-ylmethanol hydrochloride?
Chemical properties
white to off-white crystalline powder
Originator
Frenquel,Merrell,US,1955
Manufacturing Process
A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum
oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen
at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours.
The solution is filtered and the filtrate evaprated under reduced pressure. The
residue is dissolved in a mixture of equal parts of methanol and butanone and
0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and
filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283-
285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment
with ammonia and when so obtained has a melting point of 160-161°C.
brand name
Frenquel (Marion Merrell Dow).
Therapeutic Function
Tranquilizer
Properties of Diphenylpiperidin-4-ylmethanol hydrochloride
Melting point: | 270-281 °C |
form | Crystalline Powder |
color | White to off-white |
CAS DataBase Reference | 1798-50-1(CAS DataBase Reference) |
Safety information for Diphenylpiperidin-4-ylmethanol hydrochloride
Computed Descriptors for Diphenylpiperidin-4-ylmethanol hydrochloride
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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