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HomeProduct name listDiphenylpiperidin-4-ylmethanol hydrochloride

Diphenylpiperidin-4-ylmethanol hydrochloride

  • CAS NO.:1798-50-1
  • Empirical Formula: C18H22ClNO
  • Molecular Weight: 303.83
  • MDL number: MFCD00039039
  • EINECS: 217-284-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 15:13:19
Diphenylpiperidin-4-ylmethanol hydrochloride Structural

What is Diphenylpiperidin-4-ylmethanol hydrochloride?

Chemical properties

white to off-white crystalline powder

Originator

Frenquel,Merrell,US,1955

Manufacturing Process

A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours. The solution is filtered and the filtrate evaprated under reduced pressure. The residue is dissolved in a mixture of equal parts of methanol and butanone and 0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283- 285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment with ammonia and when so obtained has a melting point of 160-161°C.

brand name

Frenquel (Marion Merrell Dow).

Therapeutic Function

Tranquilizer

Properties of Diphenylpiperidin-4-ylmethanol hydrochloride

Melting point: 270-281 °C
form  Crystalline Powder
color  White to off-white
CAS DataBase Reference 1798-50-1(CAS DataBase Reference)

Safety information for Diphenylpiperidin-4-ylmethanol hydrochloride

Computed Descriptors for Diphenylpiperidin-4-ylmethanol hydrochloride

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