Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listfenbutrazate

fenbutrazate

  • CAS NO.:4378-36-3
  • Empirical Formula: C23H29NO3
  • Molecular Weight: 367.48
  • MDL number: MFCD00864478
  • EINECS: 224-480-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-03-19 15:37:50
fenbutrazate Structural

What is fenbutrazate?

Originator

Phenbutrazate,Shanghai Lansheng

The Uses of fenbutrazate

Fenbutrazate is a derivative of Phenmetrazine (P314500). Fenbutrazate is a psychostimulant used as an anorexigen (appetite suppressant).

Definition

ChEBI: Fenbutrazate is a member of morpholines.

Manufacturing Process

1105 g of 2-phenyl-3-methyl-4-(α-hydroxyethyl)-tetrahydro-1,4-oxazine-(4- (2-hydroxyethyl)-3-methyl-2-phenylmorphotine) are dissolved in 4000 ml of anhydrous toluene. 910 g of α-phenyl-α-ethyl acetic acid chloride (2-ethyl-2- phenyl-acetylchloride) are dissolved in 400 ml of anhydrous toluene and the resulting solution is slowly added to the heated solution of the tetrahydro-1,4- oxazine compound. The mixture is then heated to boiling for about 5 hours. About 1000 g of ice are added to the cooled reaction mixture, which is then rendered alkaline by the addition of 20% sodium carbonate solution to a pH of 9.0. Thereafter the mixture is vigorously stirred by means of a turbine mixer for one hour and the toluene phase is separated. The toluene solution is washed with 1000 ml of saturated sodium chloride solution and is dried over anhydrous sodium sulfate. The toluene is then evaporated and the residue is subjected to high vacuum distillation. 1650 g of α-phenyl-α-ethylacetic acid (2-phenyl-3-methyltetrahydro-1,4-oxazine)-N-ethyl ester (fenburazate), boiling at 235°-240°C/0.05 mm are obtained thereby in a yield of 90.5% of the theoretical yield.

Therapeutic Function

Anorexic, Central stimulant

Synthesis

Phenbutrazate is prepared by condensing Nhydroxyethylphenmetrazine (R = CH2CH2OH) with 2-phenylbutyric acid. The N-hydroxyethyl compound is obtained in the same manner as phendimetrazine .

Properties of fenbutrazate

Boiling point: bp0.05 235-240°
solubility  Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)
form  Oil to Thick Oil
color  Pale Yellow to Very Dark Orange

Safety information for fenbutrazate

Computed Descriptors for fenbutrazate

Related products of tetrahydrofuran

You may like

  • 1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    99903-60-3
    View Details
  • 88491-46-7 98%
    88491-46-7 98%
    88491-46-7
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • 1784294-80-9 98%
    1784294-80-9 98%
    1784294-80-9
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.