FAMPHUR

Synonym(s):O-(4-Dimethylsulfamoylphenyl)-O,O-dimethyl-phosphorothioate;Famophos

CAS NO.：52-85-7
Empirical Formula: C10H16NO5PS2
Molecular Weight: 325.34
MDL number: MFCD00055307
EINECS: 200-154-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 17:34:39

What is FAMPHUR?

Chemical properties

Crystalline powder. Very soluble in chloroform and carbon tetrachloride; slightly soluble in water.

The Uses of FAMPHUR

Insecticide.

Definition

ChEBI: Famphur is an organic thiophosphate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an agrochemical and an anthelminthic drug. It is functionally related to a 4-hydroxy-N,N-dimethylbenzenesulfonamide.

General Description

Crystalline powder. Very toxic. Cholinesterase inhibitor. Restricted use as insecticide.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Organothiophosphates, such as FAMPHUR, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Hazard

Cholinesterase inhibitor, use may be restricted.

Metabolism

The principal degradation routes in mammals are P?Ophenyl bond cleavage and O-demethylation. Oxidative desulfuration and N-demethylation also take place to form toxic metabolites.

Toxicity evaluation

The acute oral LD₅₀ for rats is 35–62 mg/kg.

Properties of FAMPHUR

Melting point:	53℃
Boiling point:	394.2±52.0 °C(Predicted)
Density	1.354±0.06 g/cm3(Predicted)
vapor pressure	3 x 10^-5 Pa (est. 20 °C)
Flash point:	>100 °C
storage temp.	APPROX 4°C
form	Liquid
Water Solubility	5000 (est. 20 °C)
pka	-5.18±0.70(Predicted)
Merck	13,3963
BRN	2224254
EPA Substance Registry System	Famphur (52-85-7)

Safety information for FAMPHUR

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H300:Acute toxicity,oral H311:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.