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HomeProduct name listExenatide acetate

Exenatide acetate

  • CAS NO.:141732-76-5
  • Empirical Formula: C186H286N50O62S
  • Molecular Weight: 4244.60796
  • MDL number: MFCD08704781
  • EINECS: 1592732-453-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Exenatide acetate Structural

What is Exenatide acetate?

Chemical properties

Exenatide acetate is White Solid

The Uses of Exenatide acetate

Application of exenatide acetate causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acetate acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide acetate augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide acetate has found use as a medication of diabetes II.

The Uses of Exenatide acetate

A 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.

Clinical Use

39-peptide known as an incretin mimetic; an agonist of glucagon-like peptide-1, used adjunctively in type II diabetes mellitus.

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants: possibly enhances anticoagulant effect of warfarin.
Other nephrotoxins: avoid concomitant use.

Metabolism

Exenatide is eliminated through the kidneys by glomerular filtration followed by proteolytic degradation.

Properties of Exenatide acetate

Melting point: >209°C (dec.)
storage temp.  Refrigerator, under inert atmosphere
solubility  Acetonitrile (Slightly), Water (Slightly)
form  Solid
color  White to Off-White
CAS DataBase Reference 141732-76-5(CAS DataBase Reference)

Safety information for Exenatide acetate

Computed Descriptors for Exenatide acetate

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