ETOFYLLINE CLOFIBRATE
- CAS NO.：54504-70-0
- Empirical Formula: C19H21ClN4O5
- Molecular Weight: 420.85
- MDL number: MFCD00865733
- EINECS: 259-191-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is ETOFYLLINE CLOFIBRATE?
Originator
Duolip,Merckle,W. Germany,1981
The Uses of ETOFYLLINE CLOFIBRATE
Duolip (L. Merckle, Germany).
What are the applications of Application
Etofylline clofibrate is an antioxidant shown to lower blood lipid levels
Definition
ChEBI: Etofylline clofibrate is an oxopurine.
Manufacturing Process
107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol)
7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They
were heated together for 15 hours in a water separator following the addition
of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute
sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated
in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55%
yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The
compound had a melting point of 131°C to 132°C.
Therapeutic Function
Antihyperlipidemic
Properties of ETOFYLLINE CLOFIBRATE
| Melting point: | 133-135° |
| Boiling point: | 615.8±65.0 °C(Predicted) |
| Density | 1.3758 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 52 mg/mL (123.56 mM) |
| pka | 0.17±0.70(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
Safety information for ETOFYLLINE CLOFIBRATE
Computed Descriptors for ETOFYLLINE CLOFIBRATE
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