ETHYLTHIOUREA

Synonym(s):1-Ethylthiourea

CAS NO.：625-53-6
Empirical Formula: C3H8N2S
Molecular Weight: 104.17
MDL number: MFCD00004939
EINECS: 210-899-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:44:00

What is ETHYLTHIOUREA?

The Uses of ETHYLTHIOUREA

N-Ethylthiourea was used in the preparation of Re (III) complexes, which are precursors for the new rhenium complexes, potentially useful in nuclear medicine. It was also used in two-step protocol for the first chemoselective cleavage of 2-hydroxy acid amides

What are the applications of Application

Ethylthiourea is a bactericidal precursor

Definition

ChEBI: N-ethylthiourea is a member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by an ethyl group. It is functionally related to a thiourea.

General Description

N-Ethylthiourea forms adduct with silver halides and their single crystal X-ray structural and spectroscopic characterizations are described.

Biological Activity

Potent, selective and reversible inhibitor of isoform II NO synthase (IC 50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively).

Safety Profile

Poison by ingestion. SYN: 1-ETHYLTHIOUREA Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Sox and NOx.

Purification Methods

Crystallise the thiourea from EtOH, MeOH or ether. [Beilstein 4 IV 374.]

Properties of ETHYLTHIOUREA

Melting point:	108-110 °C(lit.)
Boiling point:	132 °C
Density	1.055 (estimate)
refractive index	1.5500 (estimate)
storage temp.	Store at RT
solubility	methanol: soluble25mg/mL, clear, colorless
pka	14.97±0.29(Predicted)
form	Solid
color	White to Off-White
Water Solubility	Soluble in water (24g/L).
BRN	1699551
CAS DataBase Reference	625-53-6(CAS DataBase Reference)
EPA Substance Registry System	Ethylthiourea (625-53-6)