Ethyl picolinate

Synonym(s):Ethyl pyridine-2-carboxylate

CAS NO.：2524-52-9
Empirical Formula: C8H9NO2
Molecular Weight: 151.16
MDL number: MFCD00006292
EINECS: 219-758-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-29 11:48:30

What is Ethyl picolinate ?

Chemical properties

clear yellowish or pink liquid

The Uses of Ethyl picolinate

Ethyl picolinate can be used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.

The Uses of Ethyl picolinate

Ethyl picolinate is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors which is used in the treatment of diabetes. It is also used as pharmaceutical intermediate.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 43, p. 1028, 1995 DOI: 10.1248/cpb.43.1028

Preparation

Dissolve 2-methylpyridine in water, add potassium permanganate in batches under vigorous stirring to react in the aqueous solution, and after all the potassium permanganate has reacted, add concentrated HCl to adjust the pH value, then boil with benzene for 2 hours to extract the product 2-picolinic acid, and then prepare the Ethyl picolinate through ethanol hydrolysis reaction.

synthesis route of Ethyl picolinate

Properties of Ethyl picolinate

Melting point:	2 °C (lit.)
Boiling point:	240-241 °C (lit.)
Density	1.119 g/mL at 25 °C (lit.)
refractive index	n20/D 1.511(lit.)
Flash point:	225 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Sparingly), Methanol (Slightly)
pka	1.83±0.10(Predicted)
form	Liquid
color	Clear yellow or pink
Water Solubility	miscible
BRN	122485
CAS DataBase Reference	2524-52-9(CAS DataBase Reference)
NIST Chemistry Reference	2-Pyridinecarboxylic acid, ethyl ester(2524-52-9)
EPA Substance Registry System	Ethyl picolinate (2524-52-9)

Safety information for Ethyl picolinate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.