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HomeProduct name listEthyl diethoxyphosphinylformate

Ethyl diethoxyphosphinylformate

Synonym(s):Ethyl diethoxyphospinylformate;O,O-diethyl ethoxycarbonylphosphonate;Triethyl phosphonoformate

  • CAS NO.:1474-78-8
  • Empirical Formula: C7H15O5P
  • Molecular Weight: 210.16
  • MDL number: MFCD00009108
  • EINECS: 216-016-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-26 17:49:17
Ethyl diethoxyphosphinylformate Structural

What is Ethyl diethoxyphosphinylformate?

Chemical properties

Clear colorless to slightly yellow liquid

The Uses of Ethyl diethoxyphosphinylformate

Diethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.

General Description

for synthesis

Purification Methods

Dissolve it in Et2O, shake this with H2O (to remove any trace of NaCl impurity), dry (Na2SO4), evaporate and distil it using an efficient fractionating column. [Nylén Chem Ber 57 1035 1924, Reetz et al. J Am Chem Soc 77 3813 1955, Monson Advanced Organic Synthesis Academic Press p 89 1972, Beilstein 3 II 103.]

Properties of Ethyl diethoxyphosphinylformate

Boiling point: 135 °C12 mm Hg(lit.)
Density  1.11 g/mL at 25 °C(lit.)
refractive index  n20/D 1.423(lit.)
Flash point: >230 °F
storage temp.  Store below +30°C.
solubility  Chloroform (Slightly), Methanol (Slightly)
form  neat
color  Colorless to Almost colorless
Specific Gravity 1.11
BRN  1781949
Stability: Moisture Sensitive
CAS DataBase Reference 1474-78-8(CAS DataBase Reference)
NIST Chemistry Reference Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide(1474-78-8)
EPA Substance Registry System Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide (1474-78-8)

Safety information for Ethyl diethoxyphosphinylformate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H317:Sensitisation, Skin
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P321:Specific treatment (see … on this label).
P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

Computed Descriptors for Ethyl diethoxyphosphinylformate

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