Ethyl carbazate
Synonym(s):Hydrazinocarboxylic acid ethyl ester
- CAS NO.:4114-31-2
- Empirical Formula: C3H8N2O2
- Molecular Weight: 104.11
- MDL number: MFCD00007595
- EINECS: 223-903-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is Ethyl carbazate?
Chemical properties
Off-white crystals.
The Uses of Ethyl carbazate
Prepare 4-phenylurazole from ethyl carbazate and then oxidize the urazole with gaseous dinitrogen tetroxide to yield 4-phenyl-1,2,4-tri- azoline-3,5-dione la. Modification of the ethyl carbazate procedure in which analytically pure monoalkylhydrazine hydrochlorides were isolated in greater than 90% yield, starting from a ketone or aldehyde. Treatment of primary amines is with chloroamine or hydroxylamine-0-sulfonic acid and the condensation of a carbonyl compound with ethyl carbazate. The FeCl 3 -catalyzed reaction of ethyl carbazate (2 b) proceeded readily to give β-hydroxyester 3 b in better yield. A new one-pot neat synthesis of some 5-aryl-2,4-dihydro-3H-1,2,4-triazol-3-ones through cyclocondensation of ethyl carbazate with aryl nitriles catalyzed by DMAP as an efficient and basic nucleophilic catalyst is described.
The Uses of Ethyl carbazate
Synthetic intermediate.
Hazard
Irritant.
Purification Methods
Fractionate the carbazate using a Vigreux column (p 11) until the distillate crystallises [Allen & Bell Org Synth Coll Vol III 404 1955, Beilstein 3 IV 174].
Properties of Ethyl carbazate
Melting point: | 44-47 °C (lit.) |
Boiling point: | 108-110 °C/22 mmHg (lit.) |
Density | 1.2719 (rough estimate) |
refractive index | 1.4715 (estimate) |
Flash point: | 187 °F |
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
form | Powder |
pka | 10.72±0.20(Predicted) |
color | White to cream |
Water Solubility | Very soluble in water. |
Sensitive | Moisture Sensitive |
BRN | 878265 |
CAS DataBase Reference | 4114-31-2(CAS DataBase Reference) |
NIST Chemistry Reference | Hydrazinecarboxylic acid, ethyl ester(4114-31-2) |
EPA Substance Registry System | Hydrazinecarboxylic acid, ethyl ester (4114-31-2) |
Safety information for Ethyl carbazate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Ethyl carbazate
InChIKey | VYSYZMNJHYOXGN-UHFFFAOYSA-N |
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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