Ethyl 2-methylacetoacetate

Synonym(s):Ethyl 2-methyl-3-oxobutanoate

CAS NO.：609-14-3
Empirical Formula: C7H12O3
Molecular Weight: 144.17
MDL number: MFCD00009164
EINECS: 210-179-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-14 11:55:41

What is Ethyl 2-methylacetoacetate?

Chemical properties

clear colorless to yellow liquid

The Uses of Ethyl 2-methylacetoacetate

Ethyl 2-methylacetoacetate is used in Japp-Klingemann reaction to prepare hydrazones from beta-keto acid and aryl diazonium salts. It is used as a precursor involved in the synthesis of ethylpyruvate phenylhydrazone via reaction with benzenediazonium chloride.

The Uses of Ethyl 2-methylacetoacetate

Ethyl 2-methylacetoacetate is used as a substrate in the rhenium-catalyzed synthesis of multisubstituted aromatic compounds.
It can be employed in the synthesis of coumarin derivatives via Pechmann condensation.
It undergoes dehydration to yield conjugated alkynyl and allenyl esters.
It is also used in the total synthesis of chlorotonil A, yangjinhualine A, (+)- and (?)-saudin.

Properties of Ethyl 2-methylacetoacetate

Melting point:	-45 °C
Boiling point:	187 °C (lit.)
Density	1.019 g/mL at 25 °C (lit.)
refractive index	n20/D 1.418(lit.)
Flash point:	145 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Liquid
pka	11.98±0.46(Predicted)
Specific Gravity	1.019
color	Clear colorless to yellow
Water Solubility	IMMISCIBLE
BRN	1071742
CAS DataBase Reference	609-14-3(CAS DataBase Reference)
NIST Chemistry Reference	Butanoic acid, 2-methyl-3-oxo-, ethyl ester(609-14-3)
EPA Substance Registry System	Butanoic acid, 2-methyl-3-oxo-, ethyl ester (609-14-3)

Safety information for Ethyl 2-methylacetoacetate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H227:Flammable liquids
Precautionary Statement Codes	P403+P235:Store in a well-ventilated place. Keep cool.