Erythromycin ethylsuccinate

Chemical properties

ERYTHROMYCIN ETHYLSUCCINATE is crystals

The Uses of Erythromycin ethylsuccinate

antibacterial

The Uses of Erythromycin ethylsuccinate

Erythromycin ethylsuccinate is a broad spectrum antibiotic commonly targeting bacteria responsible for respiratory tract infections.

Definition

ChEBI: Erythromycin ethylsuccinate is a erythromycin derivative that is erythromycin A in which the hydroxy group at position 3R is substituted by a (4-ethoxy-4-oxobutanoyl)oxy group. It is used for the treatment of a wide variety of bacterial infections. It is a succinate ester, a cyclic ketone, an erythromycin derivative and an ethyl ester. It is functionally related to an erythromycin A.

brand name

E-Mycin (Pharmacia & Upjohn); E.E.S. (Abbott); Eryped (Abbott); Pediamycin (Ross); Wyamycin (Wyeth).

General Description

Erythromycin ethylsuccinate (EES, Pediamycin, EryPed) isthe ethylsuccinate mixed ester of erythromycin in which the2＇-hydroxyl group of the desosamine is esterified. It isabsorbed as the ester and hydrolyzed slowly in the body toform erythromycin. It is somewhat acid labile, and itsabsorption is enhanced by the presence of food. The ester isinsoluble in water but soluble in alcohol and ether.

Chemical properties

Erythromycin ethylsuccinate is basic and readily forms salts with acids. It is poorly soluble in water. Erythromycin ethylsuccinate is an ester of erythromycin suitable for oral administration.

Side Effects

Common side effects of erythromycin ethylsuccinate include:

nausea,

vomiting,

abdominal pain,

stomach cramping,

loss of appetite,

diarrhea,

dizziness,

headache,

feeling tired,

vaginal itching or discharge, or

mild itching or skin rash.