Erlotinib D6 HCl
- CAS NO.:1189953-78-3
- Empirical Formula: C22H18ClD6N3O4
- Molecular Weight: 435.933630668
- MDL number: MFCD09840535
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:57
What is Erlotinib D6 HCl?
Description
Erlotinib-d6 (hydrochloride) contains six deuterium atoms located on the methoxy group. It is intended for use as an internal standard for the quantification of erlotinib by GC- or LC-MS. Erlotinib is a tyrosine kinase inhibitor that acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma (HN5) tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 μM) and JAK2 mutant JAK2V617F (IC50 = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib are used to treat certain forms of cancer, including non-small cell lung cancer.
The Uses of Erlotinib D6 HCl
Erlotinib D6 HCl is a Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, Antineoplastic.;Labeled Erlotinib, intended for use as an internal standard for the quantification of Erlotinib by GC- or LC-mass spectrometry.
Properties of Erlotinib D6 HCl
storage temp. | Store at -20°C |
solubility | DMSO: slightly, heated,Methanol: slightly soluble |
form | A solid |
color | White to off-white |
Safety information for Erlotinib D6 HCl
Computed Descriptors for Erlotinib D6 HCl
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