4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
Synonym(s):4-Chloro-6,7-bis(2-methoxyethoxy)-quinazoline;PF-508367
- CAS NO.：183322-18-1
- Empirical Formula: C14H17ClN2O4
- Molecular Weight: 312.75
- MDL number: MFCD09751265
- EINECS: 605-994-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline?
The Uses of 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is an aurora 2 kinase inhibitor, PDGF inhibitor, useful in the treatment of cancer.
Description
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate. It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer compounds. It is also a synthetic intermediate in the synthesis of EGFR inhibitors, including erlotinib , with antiproliferative activity.
Properties of 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
| Melting point: | 105-107 °C |
| Boiling point: | 446.7±45.0 °C(Predicted) |
| Density | 1.257 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| pka | 0.54±0.30(Predicted) |
| color | white to off-white |
| InChI | InChI=1S/C14H17ClN2O4/c1-18-3-5-20-12-7-10-11(16-9-17-14(10)15)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3 |
| CAS DataBase Reference | 183322-18-1(CAS DataBase Reference) |
Safety information for 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
| InChIKey | ZPJLDMNVDPGZIU-UHFFFAOYSA-N |
| SMILES | N1=C2C(C=C(OCCOC)C(OCCOC)=C2)=C(Cl)N=C1 |
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