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HomeProduct name listEperisone

Eperisone

Eperisone Structural

What is Eperisone?

Originator

Myonal,Eisai,Japan,1983

Definition

ChEBI: 1-(4-ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one is an aromatic ketone that is N-propylpiperidine in which a hydrogen at positon 2 of the propyl group is replaced by a p-ethylbenzoyl group. It is a member of piperidines and an aromatic ketone.

Manufacturing Process

To 60 ml of isopropanol, there are introduced 120 g of 4-ethyl-propiophenone, 28.8g of p-formaldehyde and 107 g of piperidine hydrochloride, and the resulting mixture is heated to reflux on an oil bath with stirring. The heating is continued, and when the reaction mixture solidifies, the state being a sign of completion of the reaction, there are added 500 ml of acetone thereinto. The solidified mass is pulverized by crush, recovered by filtration and washed with acetone. 144 g of the crude dry crystalline substance is thus obtained, which is the hydrochloride of the purposed product. The hydrochloride is recrystallized from isopropanol, and there are obtained the crystalline needles having the melting point of 170°C to 172°C.

Therapeutic Function

Muscle relaxant

Properties of Eperisone

Boiling point: 386.8±35.0 °C(Predicted)
Density  0.994±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  Soluble in DMSO
pka 8.46±0.10(Predicted)
CAS DataBase Reference 64840-90-0(CAS DataBase Reference)

Safety information for Eperisone

Computed Descriptors for Eperisone

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