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HomeProduct name listDoxylamine succinate

Doxylamine succinate

Synonym(s):Doxylamine succinate salt

  • CAS NO.:562-10-7
  • Empirical Formula: C21H28N2O5
  • Molecular Weight: 388.46
  • MDL number: MFCD00056168
  • EINECS: 209-228-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 15:53:33
Doxylamine succinate Structural

What is Doxylamine succinate?

Chemical properties

white to light cream powder

The Uses of Doxylamine succinate

Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.

The Uses of Doxylamine succinate

H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.

The Uses of Doxylamine succinate

antihistaminic, hypnotic

What are the applications of Application

Doxylamine Succinate is a H1 histamine receptor antagonist

Definition

ChEBI: Doxylamine succinate is an organic molecular entity.

brand name

Decapryn (Sanofi Aventis); Unisom (Pfizer).

General Description

White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.

General Description

The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.

Air & Water Reactions

Water soluble.

Health Hazard

SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.

Fire Hazard

Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.

Biochem/physiol Actions

H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.

Properties of Doxylamine succinate

Melting point: 95-98?C
Flash point: 9℃
storage temp.  2-8°C
solubility  Very soluble in water, freely soluble in ethanol (96 per cent).
form  neat
form  Solid
color  White to Off-White
Stability: Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases.
CAS DataBase Reference 562-10-7(CAS DataBase Reference)
IARC 3 (Vol. 79) 2001
EPA Substance Registry System Doxylamine succinate (1:1) (562-10-7)

Safety information for Doxylamine succinate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for Doxylamine succinate

InChIKey KBAUFVUYFNWQFM-UHFFFAOYSA-N

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