Doxylamine succinate
Synonym(s):Doxylamine succinate salt
- CAS NO.:562-10-7
- Empirical Formula: C21H28N2O5
- Molecular Weight: 388.46
- MDL number: MFCD00056168
- EINECS: 209-228-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 21:13:59
What is Doxylamine succinate?
Chemical properties
white to light cream powder
The Uses of Doxylamine succinate
Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.
The Uses of Doxylamine succinate
H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.
The Uses of Doxylamine succinate
antihistaminic, hypnotic
What are the applications of Application
Doxylamine Succinate is a H1 histamine receptor antagonist
Definition
ChEBI: Doxylamine succinate is an organic molecular entity.
brand name
Decapryn (Sanofi Aventis); Unisom (Pfizer).
General Description
White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.
General Description
The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.
Air & Water Reactions
Water soluble.
Health Hazard
SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.
Fire Hazard
Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.
Biochem/physiol Actions
H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.
Properties of Doxylamine succinate
Melting point: | 95-98?C |
Flash point: | 9℃ |
storage temp. | 2-8°C |
solubility | Very soluble in water, freely soluble in ethanol (96 per cent). |
form | neat |
form | Solid |
color | White to Off-White |
Stability: | Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases. |
CAS DataBase Reference | 562-10-7(CAS DataBase Reference) |
IARC | 3 (Vol. 79) 2001 |
EPA Substance Registry System | Doxylamine succinate (1:1) (562-10-7) |
Safety information for Doxylamine succinate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for Doxylamine succinate
InChIKey | KBAUFVUYFNWQFM-UHFFFAOYSA-N |
Abamectin manufacturer
Malladi Drugs AND Pharmaceuticals Limited
Anugraha Chemicals
Ralington Pharma
Glyra Health Care Pvt Ltd
Urmila Chemopharma
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