Doxofylline

CAS NO.：69975-86-6
Empirical Formula: C11H14N4O4
Molecular Weight: 266.25
MDL number: MFCD00865218
EINECS: 274-239-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-20 11:41:24

What is Doxofylline?

Description

Doxofylline, a xanthine bronchodilator related to theophylline, is useful in the treatment of asthma and similar bronchospastic disorders. It has minimal activity on intestinal smooth muscle and the cardiovascular system, and is reportedly devoid of the behavioral effects of theophylline.

Description

Doxofylline is a methylxanthine bronchodilator that has been examined in clinical trials involving patients with either bronchial asthma or chronic obstructive pulmonary disease. Its mechanism of action is related to its ability to inhibit phosphodiesterase activity and, thus, increase cAMP. Compared to other xanthine derivatives, which have direct arrhythmogenic effects, doxofylline demonstrates decreased affinity towards adenosine A₁ and A₂ receptors, does not interfere with calcium influx into cells, and does not antagonize the action of calcium-channel blockers.

Originator

ABC S.p.A. (Italy)

The Uses of Doxofylline

Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as Theophylline and the evidence su pporting the effects of Doxofylline in the treatment of lung diseases.

The Uses of Doxofylline

H1 antihistamine

The Uses of Doxofylline

Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as Theophylline and the evidence supporting the effects of Doxofylline in the treatment of lung diseases.

What are the applications of Application

Doxofylline is a xanthine bronchodilator known to impede phosphodiesterase activities

Definition

ChEBI: Doxofylline is an oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma. It has a role as a bronchodilator agent, an antitussive and an anti-asthmatic drug. It is functionally related to a 7H-xanthine.

brand name

Maxivent (Roberts Pharmaceutical);ANSIMAR.

Properties of Doxofylline

Melting point:	144-146°C
Boiling point:	409.46°C (rough estimate)
Density	1.2896 (rough estimate)
RTECS	XH5135000
refractive index	1.6000 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	0.42±0.70(Predicted)
color	White to Off-White
Water Solubility	Soluble
Merck	14,3438
InChI	InChI=1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3
CAS DataBase Reference	69975-86-6(CAS DataBase Reference)

Safety information for Doxofylline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P501:Dispose of contents/container to..…