4-Pyridinecarboxaldehyde

Synonym(s):4-Pyridinecarbaldehyde;Isonicotinaldehyde;Pyridine-4-aldehyde, Isonicotinaldehyde

CAS NO.：872-85-5
Empirical Formula: C6H5NO
Molecular Weight: 107.11
MDL number: MFCD00006425
EINECS: 212-832-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

What is 4-Pyridinecarboxaldehyde?

Chemical properties

clear yellow-brown liquid. soluble in water and ether.

Preparation

4-Pyridinecarbaldehyde is synthesized by oxidation of 4-picoline. The mixed gas of 4-picoline and air is passed through the vanadium-molybdenum catalyst layer heated to 400°C, and oxidized to generate 4-pyridinecarbaldehyde.

The Uses of 4-Pyridinecarboxaldehyde

4-Pyridinecarboxaldehyde is a heterocyclic building block used to prepare Schiff bases via a Korich-type reaction.

Properties of 4-Pyridinecarboxaldehyde

Melting point:	-4--2°C
Boiling point:	71-73 °C/10 mmHg (lit.)
Density	1.137 g/mL at 20 °C (lit.)
vapor pressure	0.02 hPa (20 °C)
refractive index	n20/D 1.544(lit.)
Flash point:	130 °F
storage temp.	Store at +2°C to +8°C.
solubility	20g/l
form	liquid (clear)
pka	12.05(at 30℃)
color	clear brown-yellow
PH	7-8 (H2O, 20℃)(saturated aqueous solution)
Water Solubility	20 g/L (20 ºC)
Sensitive	Air Sensitive
BRN	105342
CAS DataBase Reference	872-85-5(CAS DataBase Reference)
NIST Chemistry Reference	4-Pyridinecarboxaldehyde(872-85-5)
EPA Substance Registry System	4-Pyridinecarboxaldehyde (872-85-5)

Safety information for 4-Pyridinecarboxaldehyde

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H314:Skin corrosion/irritation H317:Sensitisation, Skin H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.