DL-Homocysteine
Synonym(s):2-Amino-4-mercaptobutyric acid
- CAS NO.：454-29-5
- Empirical Formula: C4H9NO2S
- Molecular Weight: 135.18
- MDL number: MFCD00004898
- EINECS: 207-222-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is DL-Homocysteine?
Chemical properties
white powder
The Uses of DL-Homocysteine
DL-Homocysteine has been used to induce hyperhomocysteinemia in Sprague–Dawley rats. It has also been used to study the effects of hyperhomocysteinemia on atherosclerosis in apolipoprotein E-deficient mice.
What are the applications of Application
DL-Homocysteine is a potential marker for tumor cell growth
Definition
ChEBI: A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
Biochem/physiol Actions
Homocysteine is a sulfhydryl-containing amino acid, synthesized from methionine. It is a non-essential, non-proteinogenic amino acid. It is an important determinant of the methylation cycle and is present in the plasma in four forms. An abnormally high level of homocysteine leads to hyperhomocysteinemia and also promotes atherosclerosis.
Purification Methods
Purify it as for the L-isomer. [Allen & Steinmann J Am Chem Soc 74 3932 1952, and references for the L-isomer above, Beilstein 4 IV 3189.]
Properties of DL-Homocysteine
| Melting point: | 232-233 °C(lit.) |
| Boiling point: | 299.7±35.0 °C(Predicted) |
| Density | 1.149 (estimate) |
| refractive index | 1.5480 (estimate) |
| Flash point: | >230 °F |
| storage temp. | -20°C |
| solubility | H2O: soluble |
| form | solid |
| pka | 2.22, 8.87, 10.86(at 25℃) |
| color | White to Off-White |
| optical activity | [α]/D 0±1°, c = 1 in H2O |
| Merck | 14,4734 |
| BRN | 1721683 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 454-29-5(CAS DataBase Reference) |
Safety information for DL-Homocysteine
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08  Environment GHS09 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H372:Specific target organ toxicity, repeated exposure H413:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P501:Dispose of contents/container to..… |
Computed Descriptors for DL-Homocysteine
| InChIKey | FFFHZYDWPBMWHY-UHFFFAOYSA-N |
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