DL-Homocysteine

Synonym(s):2-Amino-4-mercaptobutyric acid

CAS NO.：454-29-5
Empirical Formula: C4H9NO2S
Molecular Weight: 135.18
MDL number: MFCD00004898
EINECS: 207-222-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-06 15:28:16

What is DL-Homocysteine?

Chemical properties

white powder

The Uses of DL-Homocysteine

DL-Homocysteine has been used to induce hyperhomocysteinemia in Sprague–Dawley rats. It has also been used to study the effects of hyperhomocysteinemia on atherosclerosis in apolipoprotein E-deficient mice.

What are the applications of Application

DL-Homocysteine is a potential marker for tumor cell growth

Definition

ChEBI: A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.

Biochem/physiol Actions

Homocysteine is a sulfhydryl-containing amino acid, synthesized from methionine. It is a non-essential, non-proteinogenic amino acid. It is an important determinant of the methylation cycle and is present in the plasma in four forms. An abnormally high level of homocysteine leads to hyperhomocysteinemia and also promotes atherosclerosis.

Purification Methods

Purify it as for the L-isomer. [Allen & Steinmann J Am Chem Soc 74 3932 1952, and references for the L-isomer above, Beilstein 4 IV 3189.]

Properties of DL-Homocysteine

Melting point:	232-233 °C(lit.)
Boiling point:	299.7±35.0 °C(Predicted)
Density	1.149 (estimate)
refractive index	1.5480 (estimate)
Flash point:	>230 °F
storage temp.	-20°C
solubility	H2O: soluble
form	solid
pka	2.22, 8.87, 10.86(at 25℃)
color	White to Off-White
optical activity	[α]/D 0±1°, c = 1 in H2O
Merck	14,4734
BRN	1721683
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	454-29-5(CAS DataBase Reference)

Safety information for DL-Homocysteine

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H372:Specific target organ toxicity, repeated exposure H413:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P501:Dispose of contents/container to..…