DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID
Synonym(s):DL -2-Amino-5-phosphonovaleric acid;5-Phosphono-DL -norvaline;AP-5;APV
- CAS NO.：76326-31-3
- Empirical Formula: C5H12NO5P
- Molecular Weight: 197.13
- MDL number: MFCD00010515
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID?
The Uses of DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID
DL-2-Amino-5-phosphonopentanoic acid has been used:
- in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses
- used in growth medium for inhibition of electrical activity in the neuronal network
- used to isolate N-methyl-D-aspartate receptors (NMDAR) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product
- used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)
What are the applications of Application
DL-2-Amino-5-phosphonovaleric acid (AP5) is a potent N-methyl-D-aspartate antagonist, reported to reverse NMDA inhibition of glutamate.
Definition
ChEBI: The 5-phosphono derivative of 2-aminopentanoic acid; acts as an N-methyl-D-aspartate receptor antagonist.
Biological Activity
Potent NMDA antagonist. See separate isomers (D-(-)-2-Amino-5-phosphonopentanoic acid and L-(+)-2-Amino-5-phosphonopentanoic acid ).
Biochem/physiol Actions
Anticonvulsant; potent and selective NMDA receptor antagonist.
storage
Room temperature
Properties of DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID
| Melting point: | 238-245oC |
| Boiling point: | 482.1±55.0 °C(Predicted) |
| Density | 1.529±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | NH4OH 1 M: 50 mg/mL, clear, colorless |
| form | solid |
| pka | 2.46±0.10(Predicted) |
| color | white |
| Water Solubility | Soluble to 10 mM in water and to 100 mM in 1eq. NaOH |
| BRN | 2446389 |
| CAS DataBase Reference | 76326-31-3(CAS DataBase Reference) |
Safety information for DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID
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