DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID

Synonym(s):DL-2-Amino-5-phosphonovaleric acid;5-Phosphono-DL-norvaline;AP-5;APV

DL-2-Amino-5-phosphonopentanoic acid has been used:

in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses
used in growth medium for inhibition of electrical activity in the neuronal network
used to isolate N-methyl-D-aspartate receptors (NMDAR) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product
used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)

DL-2-Amino-5-phosphonovaleric acid (AP5) is a potent N-methyl-D-aspartate antagonist, reported to reverse NMDA inhibition of glutamate.

ChEBI: The 5-phosphono derivative of 2-aminopentanoic acid; acts as an N-methyl-D-aspartate receptor antagonist.

Potent NMDA antagonist. See separate isomers (D-(-)-2-Amino-5-phosphonopentanoic acid and L-(+)-2-Amino-5-phosphonopentanoic acid ).

Anticonvulsant; potent and selective NMDA receptor antagonist.

Room temperature

Melting point:	238-245oC
Boiling point:	482.1±55.0 °C(Predicted)
Density	1.529±0.06 g/cm3(Predicted)
storage temp.	Store at RT
solubility	NH₄OH 1 M: 50 mg/mL, clear, colorless
form	solid
pka	2.46±0.10(Predicted)
color	white
Water Solubility	Soluble to 10 mM in water and to 100 mM in 1eq. NaOH
BRN	2446389
CAS DataBase Reference	76326-31-3(CAS DataBase Reference)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.