(R)-CPP
Synonym(s):R-(−)-3-(2-Carboxypiperazin-4-yl)propanephosphonic acid
- CAS NO.:126453-07-4
- Empirical Formula: C8H17N2O5P
- Molecular Weight: 252.2
- MDL number: MFCD00153786
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is (R)-CPP?
Description
(R)-CPP is an NMDA receptor antagonist (Ki = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with Ki values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 μmol/kg).
The Uses of (R)-CPP
(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.
What are the applications of Application
(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism
Biological Activity
Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively).
storage
Room temperature (desiccate)
Properties of (R)-CPP
Boiling point: | 546.7±60.0 °C(Predicted) |
Density | 1.408±0.06 g/cm3(Predicted) |
storage temp. | Desiccate at RT |
solubility | Water: 100mM |
pka | 1.89±0.20(Predicted) |
form | White crystalline powder. |
color | White to off-white |
Water Solubility | Soluble to 100 mM in water |
Safety information for (R)-CPP
Computed Descriptors for (R)-CPP
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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