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HomeProduct name list(R)-CPP

(R)-CPP

Synonym(s):R-(−)-3-(2-Carboxypiperazin-4-yl)propanephosphonic acid

(R)-CPP Structural

What is (R)-CPP?

Description

(R)-CPP is an NMDA receptor antagonist (Ki = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with Ki values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 μmol/kg).

The Uses of (R)-CPP

(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.

What are the applications of Application

(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism

Biological Activity

Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively).

storage

Room temperature (desiccate)

Properties of (R)-CPP

Boiling point: 546.7±60.0 °C(Predicted)
Density  1.408±0.06 g/cm3(Predicted)
storage temp.  Desiccate at RT
solubility  Water: 100mM
pka 1.89±0.20(Predicted)
form  White crystalline powder.
color  White to off-white
Water Solubility  Soluble to 100 mM in water

Safety information for (R)-CPP

Computed Descriptors for (R)-CPP

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