Disodium edetate dihydrate
Synonym(s):Edetate Disodium;EDTA disodium salt;Edetate disodium dihydrate;Ethylenediaminetetraacetic acid disodium salt dihydrate;Disodium ethylenediaminetetraacetate dihydrate
- CAS NO.：6381-92-6
- Empirical Formula: C10H19N2NaO9
- Molecular Weight: 334.26
- MDL number: MFCD00150037
- EINECS: 613-386-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:57
What is Disodium edetate dihydrate?
Chemical properties
White or almost white, crystalline powder.
The Uses of Disodium edetate dihydrate
Ethylenediaminetetraacetic acid disodium salt dihydrate is used as chelating agent for metals and as pharmaceutic aid (chelating agent). It inhibits enzymes such as metalloproteases that require divalent cations for activity. It is also used in chelation therapy. It acts as a sequestering agent in shampoos, cleaners and other personal care products and serves as an anticoagulant for blood samples.
Definition
ChEBI: A hydrate that is the dihydrate form of EDTA disodium salt.
General Description
Ethylenediaminetetraacetic acid disodium salt dehydrate is designated as Molecular Biology grade and is suitable for molecular biology applications. It has been analyzed for the presence of nucleases and proteases.
Biochem/physiol Actions
Zinc-dependent metalloproteinases, as well as other proteases that are stabilized by calcium, can be effectively inhibited by chelation of divalent metal ions with EDTA. Other chelators such as EGTA, specific for calcium, and 1,10-phenanthroline, highly specific for zinc, can be used to target these two different types of proteases.
Properties of Disodium edetate dihydrate
| Melting point: | 250 °C (dec.)(lit.) |
| Boiling point: | >100 °C |
| Density | 1.01 g/mL at 25 °C |
| refractive index | n |
| FEMA | 4520 | ETHYLENEDIAMINETETRAACETIC ACID DISODIUM SALT |
| Flash point: | >100℃ |
| storage temp. | room temp |
| solubility | 3 M NaOH: 100 mg/mL |
| form | crystalline |
| pka | pK1:1.99;pK2:2.67;pK3:6.16;pK4:10.26 (25°C) |
| color | ≤5 (0.5 M)(APHA) |
| PH | 4.0-5.5 (25℃, 0.1M in H2O) |
| Odor | Odorless |
| PH Range | 4 - 5 at 10 g/l at 23 °C |
| Water Solubility | soluble |
| λmax | λ: 260 nm Amax: 0.145 λ: 280 nm Amax: 0.025 |
| BRN | 3900609 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 6381-92-6(CAS DataBase Reference) |
| EPA Substance Registry System | Ethylenediaminetetraacetic acid disodium salt dihydrate (6381-92-6) |
Safety information for Disodium edetate dihydrate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H332:Acute toxicity,inhalation H373:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P314:Get medical advice/attention if you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Disodium edetate dihydrate
| InChIKey | QCDUWWPHAVXXQS-UHFFFAOYSA-L |
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