DIHYDROSAFROL

Description

Dihydrosafrole is an oily liquid. Molecularweight=164.22; Boiling point=228℃; Wiswesser linenotation: T56 BO DO CHJ G3.

Chemical properties

Light Yellow Oil

Occurrence

Has apparently not been reported to occur in nature.

The Uses of DIHYDROSAFROL

Safrole derivative. Carcinogenic.

Preparation

By catalytic hydrogenation of safrole (Arctander, 1969).

Definition

ChEBI: Dihydrosafrole is a member of benzodioxoles.

Toxicity evaluation

The acute oral LD₅₀ was reported as 2.26 g/kg (1.84-2.78 g/kg) in rats and as 4.30 g/kg in the mouse (Jenner, Hagan, Taylor, Cook & Fitzhugh, 1964). The acute dermal LD₅₀ in rabbits was reported as > 5 g/kg (Shelanski & Moldovan, 1973). Daily dosage for 4 days with 770 mg dihydrosafrole/kg caused macroscopic liver lesions and one death in six treated rats (Taylor, Jenner & Jones, 1964).

General Description

Oily liquid.

Health Hazard

Inhalation of material may be harmful. Contact may cause burns to skin and eyes. Inhalation of Asbestos dust may have a damaging effect on the lungs. Fire may produce irritating, corrosive and/or toxic gases. Some liquids produce vapors that may cause dizziness or suffocation. Runoff from fire control may cause pollution.

Fire Hazard

Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion and intraperitoneal routes. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Potential Exposure

Tumorigen,Mutagen, Primary Irritant. Workers may be exposed todihydrosafrole during its use as a chemical intermediate inthe production of piperonyl butoxide and related insecticidalsynergists; and in the production of fragrances for cosmeticproducts.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

storage

Color Code—Blue: Health Hazard/Poison: Store in asecure poison location. Prior to working with this chemical youshould be trained on its proper handling and storage. Store intightly closed containers in a cool, well-ventilated area awayfrom oxidizers and reducing agents. Where possible, automatically pump liquid from drums or other storage containers toprocess containers. A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHA Standard 1910.1045.

Shipping

The name of this material is not on the DOT listof materials for label and packaging standards. However,based on regulations, it may be classified as anEnvironmentally hazardous substances, liquid, n.o.s. It fallsin Hazard Class 9 and Packing Group III.[20,21]