HARRINGTONINE
- CAS NO.：26833-85-2
- Empirical Formula: C28H37NO9
- Molecular Weight: 531.6
- MDL number: MFCD28978177
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is HARRINGTONINE?
Description
The full structure of harringtonine has now been established from a study of the hydrolysis products of this base.
Description
Harringtonine is a natural alkaloid that inhibits protein synthesis at low micromolar concentrations. It immobilizes ribosomes immediately after the initiation of translation. While harringtonine has drawn some interest in mitigating cancer, its homolog homoharrington is more effective, particularly for chronic myelogenous leukemia. The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-
Chemical properties
White Solid
The Uses of HARRINGTONINE
specific anti-leukemia drug
The Uses of HARRINGTONINE
A natural product with significant antitumor activities.
Definition
ChEBI: Harringtonine is an alkaloid.
What are the applications of Application
Harringtonin is a natural alkaloid compound with antitumor properties, and an inhibitor of translation.
References
Mikolajczak, Powell, Smith, Tetrahedron, 28, 1995 (1972)
Kelly, McKenna, Christenson, Tetrahedron Lett., 35m (1973)
Properties of HARRINGTONINE
| Melting point: | 73～75℃ |
| Boiling point: | 679.4±55.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml |
| form | A crystalline solid |
| pka | 11.62±0.29(Predicted) |
| color | White to light yellow |
Safety information for HARRINGTONINE
Computed Descriptors for HARRINGTONINE
HARRINGTONINE manufacturer
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