HARRINGTONINE

CAS NO.：26833-85-2
Empirical Formula: C28H37NO9
Molecular Weight: 531.6
MDL number: MFCD28978177
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is HARRINGTONINE?

Description

The full structure of harringtonine has now been established from a study of the hydrolysis products of this base.

Description

Harringtonine is a natural alkaloid that inhibits protein synthesis at low micromolar concentrations. It immobilizes ribosomes immediately after the initiation of translation. While harringtonine has drawn some interest in mitigating cancer, its homolog homoharrington is more effective, particularly for chronic myelogenous leukemia. The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-protected mRNA fragments for evaluating translation.

Chemical properties

White Solid

The Uses of HARRINGTONINE

A natural product with significant antitumor activities.

The Uses of HARRINGTONINE

specific anti-leukemia drug

What are the applications of Application

Harringtonin is a natural alkaloid compound with antitumor properties, and an inhibitor of translation.

Definition

ChEBI: Harringtonine is an alkaloid.

References

Mikolajczak, Powell, Smith, Tetrahedron, 28, 1995 (1972)
Kelly, McKenna, Christenson, Tetrahedron Lett., 35m (1973)

Properties of HARRINGTONINE

Melting point:	73～75℃
Boiling point:	679.4±55.0 °C(Predicted)
Density	1.35±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form	A crystalline solid
pka	11.62±0.29(Predicted)
color	White to light yellow