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HomeProduct name listDiethylenetriaminepentaacetic acid

Diethylenetriaminepentaacetic acid

Synonym(s):DTPA;Diethylenetriaminepentaacetic acid;Pentetic acid;Titriplex V;DETAPAC

  • CAS NO.:67-43-6
  • Empirical Formula: C14H23N3O10
  • Molecular Weight: 393.35
  • MDL number: MFCD00004289
  • EINECS: 200-652-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 21:13:59
Diethylenetriaminepentaacetic acid Structural

What is Diethylenetriaminepentaacetic acid?

Absorption

DTPA and its trisodium salts present a very poor bioavailability after oral administration. Therefore, the normal administration of DTPA is done by slow intravenous infusion or inhalation with a nebulizer. When inhaled, the absorption is of about 20% of the administered dose.

Toxicity

Some toxicity has been reported related to administration of pentetic acid including depletion of trace metals, kidney and liver vacuolization and small bowel hemorrhage lesions.

Chemical properties

Pentetic acid occurs as a white crystalline solid and is almost odorless.

Chemical properties

Diethylenetriaminepentaacetic acid is a solid.

The Uses of Diethylenetriaminepentaacetic acid

Diethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers.

The Uses of Diethylenetriaminepentaacetic acid

chelating agent, diagnostic aid

The Uses of Diethylenetriaminepentaacetic acid

Diethylenetriaminepentaacetic acid is used as chelating agent and forms complexes with metal ions. It finds application as a magnetic resonance imaging (MRI) contrasting agent, since it improves the image by forming a complex with a gadolinium ion. It can also be used for treatment of radioactive materials such as plutonium, americium and other actinides. It is an active component of manganese and zinc fertilizers used in agrochemical industry. It acts as a color inhibitor and is used in the production of acrylon. It is also used in soaps as a water softener.

Indications

DTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides. It is FDA approved for the treatment of individuals with known or suspected internal contamination with plutonium, americium or curium to increase the rates of elimination.
Due to the pharmacokinetic elimination by the kidneys, pentetic acid conjugated with technetium Tc-99m is being used clinically to estimate physiological parameters such as glomerular filtration rat and effective renal plasma flow.

Background

Pentetic acid, also known as diethylenetriaminepentaacetic acid (DTPA), is a synthetic polyamino carboxylic acid with eight coordinate bond forming sites that can sequester metal ions and form highly stable DTPA-metal ion complexes. DTPA, along with its calcium and zinc trisodium salts, are the only FDA approved agents for the treatment of internal contamination by transuranics. It is currently considered, in all the dosage forms, as a member of the list of approved inactive ingredients for drug products by the FDA. DPTA was developed by the pharmaceutical company CIS US and FDA approved on April 14, 2004.

What are the applications of Application

Diethylenetriaminepentaacetic acid is an aminopolycarboxylic acid

Production Methods

Pentetic acid is a pentaacetic acid triamine formed during the preparation of the amino carboxylic acid and its salt.

Definition

ChEBI: Pentetic acid is a pentacarboxylic acid. It has a role as a copper chelator. It is a conjugate acid of a pentetate(1-).

General Description

Visit our Titration Center to learn more.

Pharmaceutical Applications

Pentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging.It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy.Pentetic acid–isotope complexes have also been considered as model active substances in scintigraphic imaging studies.Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.

Pharmacokinetics

There are reports in vivo of low stability of complexes of DPTA with uranium and neptunium which is being reported to cause deposition of the radionuclides into the tissues. In the case of plutonium, some preclinical studies have shown a very high urine elimination efficacy 1 hour after initial contamination. This efficacy is conserved for approximately 24 hours while the radiocontaminant is circulating. When the radionuclide is inhaled, it has been reported a DPTA-induced reduction of even 98% of the lung deposits. It is important to consider that pentetic acid can bind directly to other trace metals in the body which can cause deficiencies.

Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.

Safety

Pentetic acid is used in intrathecal and intravenous injection preparations. The pure form of pentetic acid is moderately toxic by the intraperitoneal route.
LD50 (mouse, IP): 0.54 g/kg
LD50 (mouse, oral): 4.84 g/kg

Metabolism

Pentetic acid and its derivatives present a very minimal metabolism in the body.

storage

The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.

Purification Methods

Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]

Incompatibilities

The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.

Regulatory Status

Included in the FDA Inactive Ingredients Database (intrathecal and intravenous injections). Included in intravenous and intra-articular injections licensed in the UK.

Properties of Diethylenetriaminepentaacetic acid

Melting point: 219-220 °C (lit.)
Boiling point: 517.84°C (rough estimate)
Density  1.56
refractive index  1.5700 (estimate)
Flash point: 200 °C
storage temp.  room temp
solubility  0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
form  Crystalline Powder
pka pK1:;pK2:2.55(+1);pK3:4.33(+2);pK4:8.60(-3);pK5,10.58 (25°C)
color  White to almost white
PH 2-3 (H2O, 20℃)(saturated solution)
Water Solubility  5 g/L (20 ºC)
Merck  14,7125
BRN  1810219
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 67-43-6(CAS DataBase Reference)
NIST Chemistry Reference N,N-Bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine(67-43-6)
EPA Substance Registry System Pentetic acid (67-43-6)

Safety information for Diethylenetriaminepentaacetic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H373:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Diethylenetriaminepentaacetic acid

InChIKey QPCDCPDFJACHGM-UHFFFAOYSA-N

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