Dideoxyadenosine

Synonym(s):2′,3′-Dideoxyadenosine;ddA

CAS NO.：4097-22-7
Empirical Formula: C10H13N5O2
Molecular Weight: 235.24
MDL number: MFCD00010534
EINECS: 223-853-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-02 19:02:54

What is Dideoxyadenosine?

Chemical properties

Beige power

The Uses of Dideoxyadenosine

2′,3′-Dideoxyadenosine (ddA), a specific adenylyl cyclase inhibitor, is useful in biological process and pathway studies involving adenylyl cyclase activity and cAMP pool modulation.

The Uses of Dideoxyadenosine

A potent labelled anti-HIV agent.

The Uses of Dideoxyadenosine

A potent anti-HIV agent.

The Uses of Dideoxyadenosine

Dideoxy Adenosine (Didanosine EP Impurity G) is a potent anti-HIV agent.

What are the applications of Application

2′,3′-Dideoxyadenosine is an inhibitor of adenylate cyclase and adenosine deaminase

Definition

ChEBI: A purine 2',3'-dideoxyribonucleoside in which the nucleobase component is specified as adenine.

General Description

Off-white powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Dideoxyadenosine may be sensitive to prolonged exposure to light.

Health Hazard

SYMPTOMS: Symptoms of exposure to a related compound include cutaneous eruptions, fever, mouth sores, thrombocytopenia, neutropenia, reversible peripheral neuropathy, gastrointestinal distress, headache, nausea and vomiting.

Fire Hazard

Flash point data for Dideoxyadenosine are not available; however, Dideoxyadenosine is probably combustible.

Properties of Dideoxyadenosine

Melting point:	181-184 °C(lit.)
Boiling point:	377.64°C (rough estimate)
alpha	D25 -25.2° (c = 1.01 in water)
Density	1.2455 (rough estimate)
refractive index	-34 ° (C=1, H2O)
storage temp.	-20°C
solubility	DMF: 1 mg/mL; DMSO: 2 mg/mL; Ethanol: Slightly soluble
pka	pKa 3.84(H2O t=25.0±0. I=0.01) (Uncertain)
form	Powder
color	White to Off-white
Water Solubility	43.2g/L(25 ºC)
Merck	14,3101
BRN	619924
CAS DataBase Reference	4097-22-7(CAS DataBase Reference)
EPA Substance Registry System	Adenosine, 2',3'-dideoxy- (4097-22-7)

Safety information for Dideoxyadenosine

Signal word	Warning
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H303:Acute toxicity,oral H341:Germ cell mutagenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..…