Dicyclohexano-18-crown-6

Synonym(s):2,3,11,12-Dicyclohexano-1,4,7,10,13,16-hexaoxacyclooctadecane;2,5,8,15,18,21-Hexaoxatricyclo[20.4.0.0^9.14]hexacosane;2,5,8,15,18,21-Hexaoxatricyclo[20.4.0.09.14] hexacosane, Dicyclohexyl-18-crown-6;Crown ether/Dicyclohexyl-18-crown-6;Dicyclohexyl-18-crown-6

CAS NO.：16069-36-6
Empirical Formula: C20H36O6
Molecular Weight: 372.5
MDL number: MFCD00005099
EINECS: 240-216-4
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is Dicyclohexano-18-crown-6?

Chemical properties

White solid

The Uses of Dicyclohexano-18-crown-6

Dicyclohexano is used as an anion activator and complexing agent which solubilizes alkali metal ions in non-polar solvents. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs etc,.

The Uses of Dicyclohexano-18-crown-6

Anion activator, and complexing agent which solubilizes alkali metal ions in non-polar solvents.

Safety Profile

Poison by ingestion, skin contact, and intraperitoneal routes. An experimental teratogen. An eye and skin irritant. When heated to decomposition it emits acrid smoke and fumes.

Purification Methods

Purify it by chromatography on neutral alumina and eluting with an ether/hexane mixture [see Izatt et al. Inorg Chem 14 3132 1975]. Dissolve it in ether at ca 40o, and spectroscopic grade MeCN is added to the solution, which is then chilled. The crown ether precipitates and is filtered off. It is dried in vacuo at room temperature [Wallace J Phys Chem 89 1357 1985]. [V.gtle ed. Top Corr Chem (Host Guest Complex Chemistry) 98 1981.] SKIN IRRITANT.

Properties of Dicyclohexano-18-crown-6

Melting point:	47-50 °C
Boiling point:	344°C
Density	1.102 g/cm
refractive index	1.4909
Flash point:	113 °C
storage temp.	Store below +30°C.
form	Crystalline Solid
color	White to slightly beige
Water Solubility	Slightly soluble
Sensitive	Hygroscopic
Merck	14,2602
BRN	1130529
CAS DataBase Reference	16069-36-6(CAS DataBase Reference)
NIST Chemistry Reference	Dicyclohexano-18-crown-6(16069-36-6)
EPA Substance Registry System	Dibenzo[b,k][1,4,7,10,13,16]hexaoxacyclooctadecin, eicosahydro- (16069-36-6)

Safety information for Dicyclohexano-18-crown-6

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.