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HomeProduct name listDi-o-tolylguanidine

Di-o-tolylguanidine

Synonym(s):DTG

  • CAS NO.:97-39-2
  • Empirical Formula: C15H17N3
  • Molecular Weight: 239.32
  • MDL number: MFCD00008513
  • EINECS: 202-577-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:08:52
Di-o-tolylguanidine Structural

What is Di-o-tolylguanidine?

Description

DTG (97-39-2) is an agonist of the sigma (σ) receptor1?with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2.

The Uses of Di-o-tolylguanidine

DTG is a selective ligand for the sigma-binding site. DTG has high binding affinity.

What are the applications of Application

DTG is a sigma receptor that displays a high affinity for σ1 and σ2 receptors

Definition

ChEBI: 1,2-bis(2-methylphenyl)guanidine is a member of toluenes.

General Description

1,3-Di-o-tolylguanidine is a selective σ-receptor agonist. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice.

Flammability and Explosibility

Non flammable

Biological Activity

Displays high and roughly equal affinity for both σ 1 and σ 2 receptors.

Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

The guanidine crystallises from aqueous EtOH. The sulfate has m 253-254o(dec, H2O). [Beilstein 12 H 803, 12 II 445, 12 III 1871, 16 IV 1764]

References

1) Weber?et al.?(1986),?1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs; Proc. Natl. Acad. Sci. USA,?83?8784 2) Scherz?et al.?(1990),?Synthesis and Structure-Activity Relationships of N,N’-Di-o-tolylguanidine Analogues, High-Affinity Ligands for the Haloperidol-Sensitive σ Receptor; J. Med. Chem.,?33?2421

Properties of Di-o-tolylguanidine

Melting point: 176-178 °C(lit.)
Boiling point: 371.98°C (rough estimate)
Density  1.1000
vapor pressure  0Pa at 25℃
refractive index  1.4560 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  water: soluble70mg/mL at 20°C
pka 10.32±0.10(Predicted)
form  solid
color  White
Water Solubility  70mg/L at 20℃
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference 97-39-2(CAS DataBase Reference)
NIST Chemistry Reference Guanidine, 1,3-di-o-tolyl-(97-39-2)
EPA Substance Registry System 1,3-Di-o-tolylguanidine (97-39-2)

Safety information for Di-o-tolylguanidine

Signal word Warning
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H301:Acute toxicity,oral
H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H317:Sensitisation, Skin
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for Di-o-tolylguanidine

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