Di-o-tolylguanidine
Synonym(s):DTG
- CAS NO.:97-39-2
- Empirical Formula: C15H17N3
- Molecular Weight: 239.32
- MDL number: MFCD00008513
- EINECS: 202-577-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 13:32:20
What is Di-o-tolylguanidine?
Description
DTG (97-39-2) is an agonist of the sigma (σ) receptor1?with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30nM)2.
The Uses of Di-o-tolylguanidine
DTG is a selective ligand for the sigma-binding site. DTG has high binding affinity.
What are the applications of Application
DTG is a sigma receptor that displays a high affinity for σ1 and σ2 receptors
Definition
ChEBI: 1,2-bis(2-methylphenyl)guanidine is a member of toluenes.
General Description
1,3-Di-o-tolylguanidine is a selective σ-receptor agonist. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice.
Flammability and Explosibility
Non flammable
Biological Activity
Displays high and roughly equal affinity for both σ 1 and σ 2 receptors.
Safety Profile
Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
The guanidine crystallises from aqueous EtOH. The sulfate has m 253-254o(dec, H2O). [Beilstein 12 H 803, 12 II 445, 12 III 1871, 16 IV 1764]
References
1) Weber?et al.?(1986),?1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs; Proc. Natl. Acad. Sci. USA,?83?8784 2) Scherz?et al.?(1990),?Synthesis and Structure-Activity Relationships of N,N’-Di-o-tolylguanidine Analogues, High-Affinity Ligands for the Haloperidol-Sensitive σ Receptor; J. Med. Chem.,?33?2421
Properties of Di-o-tolylguanidine
Melting point: | 176-178 °C(lit.) |
Boiling point: | 371.98°C (rough estimate) |
Density | 1.1000 |
vapor pressure | 0Pa at 25℃ |
refractive index | 1.4560 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | water: soluble70mg/mL at 20°C |
pka | 10.32±0.10(Predicted) |
form | solid |
color | White |
Water Solubility | 70mg/L at 20℃ |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
CAS DataBase Reference | 97-39-2(CAS DataBase Reference) |
NIST Chemistry Reference | Guanidine, 1,3-di-o-tolyl-(97-39-2) |
EPA Substance Registry System | 1,3-Di-o-tolylguanidine (97-39-2) |
Safety information for Di-o-tolylguanidine
Signal word | Warning |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H301:Acute toxicity,oral H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Di-o-tolylguanidine
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