DFMO
Synonym(s):2-(Difluoromethyl)ornithine hydrochloride hydrate;DFMO hydrochloride hydrate;Eflornithine hydrochloride hydrate
- CAS NO.：70052-12-9
- Empirical Formula: C6H12F2N2O2
- Molecular Weight: 182.17
- MDL number: MFCD00221766
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:19
What is DFMO?
Chemical properties
Off-white powder
The Uses of DFMO
DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.
Indications
Eflornithine is indicated in the treatment of facial hirsutism (excessive hair growth).
Background
Eflornithine is a prescription drug indicated in the treatment of facial hirsutism (excessive hair growth). Eflornithine hydrochloride cream for topical application is intended for use in women suffering from facial hirsutism and is sold by Allergan, Inc. under the brand name Vaniqa. Eflornithine for injection against sleeping sickness was manufactured by Sanofi Aventis and sold under the brand name Ornidyl in the USA. It is now discontinued. Eflornithine is on the World Health Organization's List of Essential Medicines.
What are the applications of Application
Difluoromethylornithine is an inhibitor of ornithine decarboxylase
Definition
ChEBI: Eflornithine is a fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. It has a role as a trypanocidal drug. It is a fluoroamino acid and an alpha-amino acid. It is functionally related to an ornithine.
General Description
Difluoromethylornithine is a?fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic?effects on mammalian cells and tissues.
Biological Activity
Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity.
Biochem/physiol Actions
Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.
Metabolism
Not metabolized
Properties of DFMO
| Melting point: | 138 °C |
| Boiling point: | 347.0±42.0 °C(Predicted) |
| Density | 1.1800 (estimate) |
| storage temp. | Store at 0°C |
| solubility | H2O: >10 mg/mL, soluble |
| form | solid |
| pka | 1.22±0.44(Predicted) |
| color | white |
Safety information for DFMO
Computed Descriptors for DFMO
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Rimegepant Impurity 3 Ivermectin EP Impurity B Fosfomycin EP impurity D Tubulysin A (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin I Tubulysin B (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin F 2-chloro-4-fluoro-5-Iodobenzophenon 3-Amino tetra hydrofuran-3-carboxylic acid-n-butylester 5-bromo-1,4-dimethyl-3-nitropyridin-2(1H)-one (1-amino-cyclobutyl)-methanol 4-(2-(piperidin-1-yl)ethoxy)benzoic acid 2-chloro-6-methyl-4-nitropyridine 1-oxide 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH 2-(3,5-Di-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneRelated products of tetrahydrofuran
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