DFMO
- CAS NO.：66640-93-5
- Empirical Formula: C6H12F2N2O2
- Molecular Weight: 182.17
- MDL number: MFCD00221766
- Update Date: 2023-05-21 10:59:17
What is DFMO?
Biological Activity
L-Eflornithine (L-DFMO) is the enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with KD of 1.3±0.3 μM and Kinact of 0.15±0.03 min-1.
in vivo
The more potent L-Eflornithine is present at much lower concentrations in both plasma and cerebrospinal fluid (CSF) than those of the D-Eflornithine. The plasma concentrations of L-Eflornithine are on average 52% of the D -enantiomer concentrations. The typical oral clearances of L-Eflornithine and D-eflornithine are 17.4 and 8.23 liters/h, respectively.
Properties of DFMO
| Boiling point: | 347.0±42.0 °C(Predicted) |
| Density | 1.293±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 1.22±0.44(Predicted) |
Safety information for DFMO
Computed Descriptors for DFMO
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde 2,3-Dibromo-5,6-dimethylpyridine Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin A Tubulysin M (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate 2-chloro-5-nitropyridin-4-amine 3-fluoro-N-(1-phenylethyl)tetrahydro-2H-pyran-4-amine 4-(Chloromethyl)-7-Hydroxy-2H-chromen-2-one QUINUCLIDINE-2-CARBONITRILE 6-bromo-5-methoxypicolinic acid Imeglimin Hydrochloride IH Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 4,8-dibromo-5H-[1,2,3]triazolo[4',5':4,5]benzo[1,2-c][1,2,5]thiadiazole 3,6-Bis(4-bromophenyl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione 1-(4-Fluorophenyl)piperidin-2-one 4-Bromo-N,N-bis(4-iodophenyl)anilineRelated products of tetrahydrofuran
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