DFMO
- CAS NO.：66640-93-5
- Empirical Formula: C6H12F2N2O2
- Molecular Weight: 182.17
- MDL number: MFCD00221766
- Update Date: 2024-10-28 23:16:16
What is DFMO?
Biological Activity
L-Eflornithine (L-DFMO) is the enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with KD of 1.3±0.3 μM and Kinact of 0.15±0.03 min-1.
in vivo
The more potent L-Eflornithine is present at much lower concentrations in both plasma and cerebrospinal fluid (CSF) than those of the D-Eflornithine. The plasma concentrations of L-Eflornithine are on average 52% of the D -enantiomer concentrations. The typical oral clearances of L-Eflornithine and D-eflornithine are 17.4 and 8.23 liters/h, respectively.
Properties of DFMO
| Boiling point: | 347.0±42.0 °C(Predicted) |
| Density | 1.293±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 1.22±0.44(Predicted) |
Safety information for DFMO
Computed Descriptors for DFMO
New Products
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