Desonide
- CAS NO.:638-94-8
- Empirical Formula: C24H32O6
- Molecular Weight: 416.51
- MDL number: MFCD00866151
- EINECS: 211-351-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is Desonide?
Absorption
Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin may increase percutaneous absorption.
Chemical properties
Off-White Solid
Originator
Tridesilon,Dome,US,1972
The Uses of Desonide
Anti-inflammatory. Desonide has also been found as an impurity in budesonide (B689490).
The Uses of Desonide
antifungal
The Uses of Desonide
Desonide(Budesonide EP Impurity F) is an impurity of Budesonide (B689490), an anti-inflammatory.
Indications
For the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatose.
Background
A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.
What are the applications of Application
Desonide is an antiinflammatory compound
Definition
ChEBI: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.
Indications
Desonide (DesOwen, Tridesilon) is a synthetic corticosteroid.
Manufacturing Process
Preparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4- Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4- pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction mixture is diluted with water (50 ml) and extracted with chloroform (3x25 ml), the combined extracts then being washed with water (30 ml) and dried over anhydrous sodium sulfate. The residue obtained by removal of solvent crystallized from ethyl acetate-petroleum ether as small plates (25 mg), melting point 257°-260°C.
brand name
Desowen (Galderma); Tridesilon (Perrigo).
Therapeutic Function
Antiinflammatory
Pharmacokinetics
Desonide is a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents.
Metabolism
Not Available
Properties of Desonide
Melting point: | 272-274?C |
Boiling point: | 580.1±50.0 °C(Predicted) |
Density | 1.30±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,2-8°C |
solubility | DMF (Slightly, Sonicated), DMSO (Sparingly), Methanol (Slightly, Heated) |
form | Solid |
pka | 12.87±0.10(Predicted) |
color | White to Off-White |
CAS DataBase Reference | 638-94-8(CAS DataBase Reference) |
Safety information for Desonide
Computed Descriptors for Desonide
Desonide manufacturer
Aarti Industries Limited (AIL)
Swati Spentose Pvt Ltd
Symbiotec Pharma Lab Pvt Ltd
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