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HomeProduct name listDesonide

Desonide

  • CAS NO.:638-94-8
  • Empirical Formula: C24H32O6
  • Molecular Weight: 416.51
  • MDL number: MFCD00866151
  • EINECS: 211-351-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 18:15:48
Desonide Structural

What is Desonide?

Absorption

Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin may increase percutaneous absorption.

Chemical properties

Off-White Solid

Originator

Tridesilon,Dome,US,1972

The Uses of Desonide

Anti-inflammatory. Desonide has also been found as an impurity in budesonide (B689490).

The Uses of Desonide

antifungal

The Uses of Desonide

Desonide(Budesonide EP Impurity F) is an impurity of Budesonide (B689490), an anti-inflammatory.

Indications

For the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatose.

Background

A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.

What are the applications of Application

Desonide is an antiinflammatory compound

Definition

ChEBI: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.

Indications

Desonide (DesOwen, Tridesilon) is a synthetic corticosteroid.

Manufacturing Process

Preparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4- Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4- pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction mixture is diluted with water (50 ml) and extracted with chloroform (3x25 ml), the combined extracts then being washed with water (30 ml) and dried over anhydrous sodium sulfate. The residue obtained by removal of solvent crystallized from ethyl acetate-petroleum ether as small plates (25 mg), melting point 257°-260°C.

brand name

Desowen (Galderma); Tridesilon (Perrigo).

Therapeutic Function

Antiinflammatory

Pharmacokinetics

Desonide is a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents.

Metabolism

Not Available

Properties of Desonide

Melting point: 272-274?C
Boiling point: 580.1±50.0 °C(Predicted)
Density  1.30±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,2-8°C
solubility  DMF (Slightly, Sonicated), DMSO (Sparingly), Methanol (Slightly, Heated)
form  Solid
pka 12.87±0.10(Predicted)
color  White to Off-White
CAS DataBase Reference 638-94-8(CAS DataBase Reference)

Safety information for Desonide

Computed Descriptors for Desonide

Abamectin manufacturer

GLP Pharma Standards

2Y
Phone:+91-9866074638
Whatsapp: +91 9866074638
product: Budesonide EP Impurity-F 638-94-8 98%
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Gonane Pharma

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Phone:+91-9819380043
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product: Desonide 99%
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Aarti Industries Limited (AIL)

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Phone:+91-9920899935
Whatsapp: +91 9920899935
product: Desonide 98%
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Molsyns Research

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Phone:+91-9586858886
Whatsapp: +91- 9586858886
product: 638-94-8 98%
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Swati Spentose Pvt Ltd

1Y
Phone:+91-2261505232
Whatsapp: 91-22-61505232
product: 638-94-8 Desonide 99%
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Ralington Pharma

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Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: Desonide 98%
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Symbiotec Pharma Lab Pvt Ltd

1Y
Phone:+917316676405
Whatsapp: +91-7316676405
product: 638-94-8 Desonide 98%
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