DEPMPO
- CAS NO.:157230-67-6
- Empirical Formula: C9H18NO4P
- Molecular Weight: 235.22
- MDL number: MFCD01074976
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:01:55
What is DEPMPO?
Description
DEPMPO (157230-67-6) is a spin trap capable of detecting oxygen, nitrogen, sulfur and carbon-centered free radicals both in vitro and in vivo. DEPMPO is useful for distinguishing between superoxide-dependent pathways of hydroxyl radical generation, and those that are superoxide independent.
Chemical properties
DEPMPO is Pale Yellow Oil
The Uses of DEPMPO
DEPMPO is a spin trap useful as a probe for free radical formation during myocardial ischemia/reperfusion injury. An analogue of DMPO
The Uses of DEPMPO
DEPMPO is the most efficient spin trap for the in vitro detection of O-, N-, S- and C-centered free radicals both invitro and invivo. It has a longer life-time than DMPO and can distinguish between superoxide-dependent and independent mechanisms that lead to the hydroxyl radical. It is less lipophilic (Kp=0.16) than DIPPMPO.
References
1) Liu et al. (1999), Evaluation of DEPMPO as a spin trapping agent in biological systems; Free Radic. Biol. Med., 26 714 2) Shi et al. (2005), Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species; Arch. Biochem. Biophys., 437 59 3) Culcasi et al. (2012), EPR spin trapping evaluation of ROS production in human fibroblasts exposed to cerium oxide nanoparticles: evidence for NADPH oxidase and mitochondrial stimulation; Chem. Biol. Interact., 199 161 4) Tampieri et al. (2019), Comment on “Water Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos; ACS Sens. E-pub. Ahead of Print [Focus Citation]
Properties of DEPMPO
Boiling point: | 412.4±34.0 °C(Predicted) |
Density | 1.14±0.1 g/cm3(Predicted) |
storage temp. | Freezer |
solubility | Soluble in Water or Ethanol. |
form | Colorless to light yellow oil. |
pka | 1.74±0.40(Predicted) |
color | Pale yellow |
Stability: | Hygroscopic Oil, Light Sensitive |
Safety information for DEPMPO
Computed Descriptors for DEPMPO
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