Deoxynojirimycin hydrochloride
Synonym(s):1,5-Dideoxy-1,5-imino-D -sorbitol hydrochloride;1-Deoxynojirimycin, Hydrochloride - CAS 73285-50-4 - Calbiochem;DNJ, HCl
- CAS NO.:73285-50-4
- Empirical Formula: C6H13NO4.ClH
- Molecular Weight: 199.63
- MDL number: MFCD00083611
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Deoxynojirimycin hydrochloride?
Description
1-Deoxynojirimycin (1-DNJ) is an iminosugar that has been found in M. alba (mulberry) leaves and has diverse biological activities. It inhibits the activities of α- and β-glucosidase (IC50s = 35 and 71 μM, respectively). 1-DNJ (5 mM) reduces the formation of N-linked complex oligosaccharides in IEC-6 cells. It inhibits HIV-1 envelope-mediated membrane fusion in CEM cells when used at a concentration of 2 mM. 1-DNJ (1-100 μg/ml) reduces the invasion and migration of B16/F10 mouse melanoma cells. It improves glucose and insulin tolerance in db/db mice when administered intravenously at doses ranging from 20 to 80 mg/kg per day for four weeks.
Chemical properties
White Crystalline Solid
The Uses of Deoxynojirimycin hydrochloride
Deoxynojirimycin inhibits mammalian glucosidase 1. As well, it inhibits intestinal and lysosmal alpha-glucosidases, beta-glucosidase from sweet almonds, pancreatic alpha-amylase and amyloglucosidase.
The Uses of Deoxynojirimycin hydrochloride
natural chitin synthase inhibitor
What are the applications of Application
1-Deoxynojirimycin Hydrochloride is a glucose analog and glucosidase I and II inhibitor
General Description
Specific glucosidase inhibitor, including trimming glucosidases I and II, that sequentially removes the three glucose residues from precursor Glc3Man9GlcNAc2 in N-linked glycan biosynthesis.
Biochem/physiol Actions
Product does not compete with ATP.
Properties of Deoxynojirimycin hydrochloride
Melting point: | 195-196°C |
storage temp. | Inert atmosphere,2-8°C |
solubility | Water (Slightly) |
form | Powder |
color | White |
Water Solubility | Soluble in water at 20mg/ml |
BRN | 3563225 |
Stability: | Hygroscopic |
CAS DataBase Reference | 73285-50-4 |
Safety information for Deoxynojirimycin hydrochloride
Computed Descriptors for Deoxynojirimycin hydrochloride
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