Deoxynojirimycin hydrochloride
Synonym(s):1,5-Dideoxy-1,5-imino-D -sorbitol hydrochloride;1-Deoxynojirimycin, Hydrochloride - CAS 73285-50-4 - Calbiochem;DNJ, HCl
- CAS NO.:73285-50-4
- Empirical Formula: C6H13NO4.ClH
- Molecular Weight: 199.63
- MDL number: MFCD00083611
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:17
What is Deoxynojirimycin hydrochloride?
Description
1-Deoxynojirimycin (1-DNJ) is an iminosugar that has been found in M. alba (mulberry) leaves and has diverse biological activities. It inhibits the activities of α- and β-glucosidase (IC50s = 35 and 71 μM, respectively). 1-DNJ (5 mM) reduces the formation of N-linked complex oligosaccharides in IEC-6 cells. It inhibits HIV-1 envelope-mediated membrane fusion in CEM cells when used at a concentration of 2 mM. 1-DNJ (1-100 μg/ml) reduces the invasion and migration of B16/F10 mouse melanoma cells. It improves glucose and insulin tolerance in db/db mice when administered intravenously at doses ranging from 20 to 80 mg/kg per day for four weeks.
Chemical properties
White Crystalline Solid
The Uses of Deoxynojirimycin hydrochloride
Deoxynojirimycin inhibits mammalian glucosidase 1. As well, it inhibits intestinal and lysosmal alpha-glucosidases, beta-glucosidase from sweet almonds, pancreatic alpha-amylase and amyloglucosidase.
The Uses of Deoxynojirimycin hydrochloride
natural chitin synthase inhibitor
What are the applications of Application
1-Deoxynojirimycin Hydrochloride is a glucose analog and glucosidase I and II inhibitor
General Description
Specific glucosidase inhibitor, including trimming glucosidases I and II, that sequentially removes the three glucose residues from precursor Glc3Man9GlcNAc2 in N-linked glycan biosynthesis.
Biochem/physiol Actions
Product does not compete with ATP.
Properties of Deoxynojirimycin hydrochloride
Melting point: | 195-196°C |
storage temp. | Inert atmosphere,2-8°C |
solubility | Water (Slightly) |
form | Powder |
color | White |
Water Solubility | Soluble in water at 20mg/ml |
BRN | 3563225 |
Stability: | Hygroscopic |
CAS DataBase Reference | 73285-50-4 |
Safety information for Deoxynojirimycin hydrochloride
Computed Descriptors for Deoxynojirimycin hydrochloride
New Products
(R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin D Tubulysin B 4,4-DIFLUOROPIPERIDINE tetrahydro-4-methyl-2H-pyran 4,4-DIFLUOROCYCLOHEXANAMINE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2,2-Difluoropropylamine hydrochloride 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 1-tosyl-3-(S)-(-)- tosyloxypyrrolidine 7-chloro-1- (2-methyl-4- nitrobenzoyl)-3,4- dihydro-1H-benzo[b] azepin-5(2H)-one Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
You may like
-
1-Deoxynojirimycin hydrochloride CAS 73285-50-4View Details
73285-50-4 -
1-Deoxynojirimycin hydrochloride CAS 73285-50-4View Details
73285-50-4 -
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
Hydrogen Gas 98%View Details
-
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8