DEOXYCHOLIC-2,2,4,4-D4 ACID
- CAS NO.:112076-61-6
- Empirical Formula: C24H40O4
- Molecular Weight: 392.58
- MDL number: MFCD00209707
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:02:48
What is DEOXYCHOLIC-2,2,4,4-D4 ACID?
Description
Deoxycholic acid-d4 (DCA-d4) is intended for use as an internal standard for the quantification of DCA (Item Nos. 20756 | 18231) by GC- or LC-MS. DCA is a secondary bile acid that is formed via microbial transformation of cholic acid in the colon. It can be conjugated to glycine or taurine to produce glycodeoxycholic acid (GDCA; ) or taurodeoxycholic acid (TDCA; ), respectively, in hepatocytes. DCA (0.2% v/v) inhibits spore germination induced by taurocholic acid (TCA; ) in seven C. difficile strains, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.02% v/v. It inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells when used at a concentration of 200 μM. Fecal and intestinal tissue levels of DCA are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet. Increased serum DCA levels have been found in patients with colorectal cancer.
The Uses of DEOXYCHOLIC-2,2,4,4-D4 ACID
Deoxycholic-2,2,4,4-d4 Acid (CAS# 112076-61-6) is a useful isotopically labeled research compound.
Definition
ChEBI: Deoxycholic acid-2,2,4,4-d4 is a deuterated compound and a deoxycholic acid.
Properties of DEOXYCHOLIC-2,2,4,4-D4 ACID
Melting point: | 171-174 °C |
Flash point: | 9℃ |
storage temp. | -20°C |
solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly) |
form | Solid |
color | White to Off-White |
Safety information for DEOXYCHOLIC-2,2,4,4-D4 ACID
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for DEOXYCHOLIC-2,2,4,4-D4 ACID
New Products
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