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HomeProduct name listCHOLIC-2,2,4,4-D4 ACID

CHOLIC-2,2,4,4-D4 ACID

CHOLIC-2,2,4,4-D4 ACID Structural

What is CHOLIC-2,2,4,4-D4 ACID?

Description

Cholic acid-d4 is intended for use as an internal standard for the quantification of cholic acid by GC- or LC-MS. Cholic acid is a primary bile acid. It is formed from cholesterol via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. Cholic acid is conjugated to glycine or taurine by bile acid-CoA:amino acid N-acyltransferase (BAAT) to produce glycocholic acid (GCA; ) and taurocholic acid (TCA; ), respectively, in the liver, and is transformed into the secondary bile acid deoxycholic acid (DCA; ) by intestinal microbiota. It induces C. difficile colony formation in an agar dilution assay when used at a concentration of 0.1% w/v. Dietary administration of cholic acid (0.4% w/w) increases serum cholesterol levels, biliary phospholipid secretion, and fecal DCA levels in rats.

The Uses of CHOLIC-2,2,4,4-D4 ACID

Cholic Acid-d4 is a labelled analog of Cholic acid (C432600) which is a choleretic produced by, and isolated from liver cells.

Definition

ChEBI: Cholic acid-2,2,4,4-d4 is a bile acid.

Properties of CHOLIC-2,2,4,4-D4 ACID

Melting point: 200-201°C (lit.)
storage temp.  Store at -20°C
solubility  DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
form  Solid
color  White to Off-White

Safety information for CHOLIC-2,2,4,4-D4 ACID

Computed Descriptors for CHOLIC-2,2,4,4-D4 ACID

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