Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listDemecarium bromide

Demecarium bromide

  • CAS NO.:56-94-0
  • Empirical Formula: C32H52Br2N4O4
  • Molecular Weight: 716.59
  • MDL number: MFCD00152376
  • EINECS: 200-301-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Demecarium bromide Structural

What is Demecarium bromide?

Chemical properties

White Solid

Originator

Humorsol ,MSD ,US,1959

The Uses of Demecarium bromide

Demecarium Bromide is an acetylcholinesterase inhibitor and veterinary medicine used to treat elevated intraocular pressure associated with primary glaucoma.

The Uses of Demecarium bromide

anticancer agent for pancreatic islet cells

The Uses of Demecarium bromide

Demecarium is a disymmetrical compound that contains two ammonium and two carbamate groups. It is a reversible cholinesterase inhibitor that is longer lasting than the others. It is used to constrict pupils, elevate intraocular pressure in treating glaucoma, and also for alleviating atropine mydriasis.

Definition

ChEBI: The methobromide salt of the N,N'-bis[3-(dimethylamino)phenyl carbamate] derivative of 2,13-diazatetradecane. It is an inhibitor of acetylcholinesterase and pseudocholinesterase, with a long duration of action. It is u ed in the treatment of chronic open-angle glaucoma: in the eye, it causes constriction of the iris sphincter muscle and the ciliary muscle, facilitating the outflow of the aqueous humor and so reducing intraocular pressure.

Manufacturing Process

N,N,N,N'-tetramethyldecamethylene diamine is reacted with phosgene in toluene under agitation. The phosgene which escapes through an ascending cooling tube together with the evolved methyl chloride is condensed in a cold trap. As soon as immixture has been completed, the temperature is raised to 100°C and the phosgene recovered in the trap is vaporized and bubbled through the solution again, the escaping gas being recondensed and returned once more. The repeated passage through the reagents of the phosgene that has not yet reacted is continued for 7 hours. When the solution is cool it is passed through a filter, the remaining phosgene is removed from the clear solution by distillation and the remainder distilled in vacuo.
A solution of 11.9 parts of m-dimethylaminophenol in 90 parts of xylene (isomer mixture) is added to a solution of sodium methylate consisting of 2.0 parts of sodium and 25 parts of methanol. The methanol is then completely removed by distillation and the temperature raised until the boiling point of the xylene is reached. The decamethylene-bis-(N-methyl carbamic chloride) is added to the remainder which contains the sodium salt of m dimethylaminophenol in the form of solid crystals. The reagent mixture is heated and maintained at a temperature of 100°C and continuously agitated. After having been cooled it is washed three times in water, three times in a 5% solution of caustic soda, and another three times in water. The xylene is then evaporated in vacuo and the oily residue freed of any remaining traces of xylene by allowing it to stand in air when the product crystallized completely. In this manner 15.6 parts of decamethylene-bis-(N-methyl carbamic acid mdimethylaminophenylester) are obtained, This is in turn reacted with methyl bromide to give the desired product. The decamethylene-bis-(N-methyl carbamic acid m-dimethylaminophenylesterbromomethylate) appears after precipitation from a solution in acetic acid with methyl ethyl ketone in the form of a finely crystalline powder with a micro melting point between 164° and 170°C.

brand name

Humorsol (Merck).

Therapeutic Function

Cholinergic (ophthalmic)

General Description

Demecarium bromide,(m-hydroxyphenyl)trimethylammonium bromide, decamethylenebis[methylcarbamate] (Humorsol), is the diester of(m-hydroxyphenyl)trimethylammonium bromide with decamethylene-bis-(methylcarbamic acid) and thus is comparableto a bis-prostigmine molecule.
It occurs as a slightly hygroscopic powder that is freelysoluble in water or alcohol. Ophthalmic solutions of the drughave a pH of 5 to 7.5. Aqueous solutions are stable and maybe sterilized by heat. Its efficacy and toxicity are comparableto those of other potent anticholinesterase inhibitor drugs. Itis a long-acting miotic used to treat wide-angle glaucomaand accommodative esotropia. Maximal effect occurs hoursafter administration, and the effect may persist for days.

Synthesis

Demecarium, N,N??-decamethylene-bis-[meta-(N-methylcarbamoyloxy)- phenyl-trimethylammonium] hydroxide (13.2.18), is made by reacting two moles of phosgene with 1,10-bis-(methylamino)-decano(N,N??-dimethyldecamethylen-1,10-diamine, giving the bis-carbamoylchloride (13.2.16), which is transformed into bis-carbamoylester (13.2.17) by reaction with two moles of the 3-dimethylaminophenol sodium salt. Reacting this with methylbromide gives demecarium (13.2.18) [49].

Synthesis_56-94-0

Veterinary Drugs and Treatments

Demecarium is a potent carbamate inhibitor that may reduce intraocular pressures for up to 48 hours in canines. Demecarium reversibly inhibits anticholinesterase thereby causing miosis. Demecarium is generally used in preventive management of the contralateral eye in canine patients after the diagnosis of an acute congestive crisis of primary glaucoma in the other eye. It is not used in secondary glaucoma. Demecarium has the advantage of once or twice daily dosing.

Properties of Demecarium bromide

Melting point: 162-167 °C (decomp)
storage temp.  Store at -20°C
solubility  DMSO:160.0(Max Conc. mg/mL);223.28(Max Conc. mM)
form  Solid
color  White
CAS DataBase Reference 56-94-0(CAS DataBase Reference)

Safety information for Demecarium bromide

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Demecarium bromide

InChIKey YHKBUDZECQDYBR-UHFFFAOYSA-L
SMILES C1(=CC=CC([N+](C)(C)C)=C1)OC(=O)N(C)CCCCCCCCCCN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1.[Br-].[Br-]

Related products of tetrahydrofuran

You may like

  • Demecarium Bromide 99%
    Demecarium Bromide 99%
    View Details
  • 1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    99903-60-3
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • 1784294-80-9 98%
    1784294-80-9 98%
    1784294-80-9
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.