Dehydrocostus lactone

Synonym(s):Dehydrocostuslactone;Guaia-4(15),10(14),11(13)-trien-12-oic acid, 6alpha-hydroxy-, gamma-lactone;(?)-Dehydrocostus lactone; Dehydrocostus lactone; Epiligulyl oxide;(3aS,6aR,9aR,9bS)-Decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one;[3aS-(3aα,6aα,9aα,9bβ)]-Decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one

CAS NO.：477-43-0
Empirical Formula: C15H18O2
Molecular Weight: 230.3
MDL number: MFCD00210277
EINECS: 225-472-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is Dehydrocostus lactone?

Description

Dehydrocostus lactone is a natural sesquiterpene first isolated from costus root, which is used in traditional medicine. Dehydrocostus lactone has diverse anti-cancer properties in cells and animal models, causing cell cycle arrest, inducing apoptosis, diminishing multidrug resistance, and suppressing angiogenesis in cancer cells. It also has anti-inflammatory actions in cells, including the inhibition of signaling through STAT1 and STAT3.

Description

A guaianolide sesquiterpene lactone extracted from costus oil. Dehydrocostuslactone is one of the components of lactone-mix, with costunolide and alantolactone, used to detect Compositae-sensitive patients.

The Uses of Dehydrocostus lactone

Dehydrocostus Lactone is a compound known to be a growth regulator in plants. Known to affect cell viability and cell cycle distribution it may be useful in the application towards drug-resistant tumors.

The Uses of Dehydrocostus lactone

Dehydrocostus lactone is the oil extracted from Saussurea lappa is used in perfumery and in the Orient for all kinds of diseases.

What are the applications of Application

Dehydrocostus Lactone is inhibitor of NF kappa B activation via disruption of TNF alpha processes

Definition

ChEBI: An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.

Contact allergens

A guaianolide sesquiterpene lactone extracted from costus oil. It is one of the components of Lactone mix, with costunolide and alantolactone, used to detect Compositae-sensitive patients.

Properties of Dehydrocostus lactone

Melting point:	57.0 to 61.0 °C
Boiling point:	140-143 °C(Press: 0.5 Torr)
Density	1.09
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Solid
color	White to Off-White
Odor	nutty
optical activity	[α]/D -14.0±3.0°, c = 1 in chloroform
λmax	206nm(MeOH)(lit.)
CAS DataBase Reference	477-43-0(CAS DataBase Reference)

Safety information for Dehydrocostus lactone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H317:Sensitisation, Skin
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.