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HomeProduct name listD-MANNOHEPTULOSE

D-MANNOHEPTULOSE

Synonym(s):D-Manno-2-heptulose

  • CAS NO.:3615-44-9
  • Empirical Formula: C7H14O7
  • Molecular Weight: 210.18
  • MDL number: MFCD00037814
  • EINECS: 222-795-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-28 13:53:23
D-MANNOHEPTULOSE Structural

What is D-MANNOHEPTULOSE?

Description

D-Glucose is phosphorylated by glucokinase and three tissue-specific hexokinases to produce glucose-6-phosphate in humans. D-Mannoheptulose is a heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM). It blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells. D-Mannoheptulose prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein. By blocking glucose phosphorylation, D-mannoheptulose causes transient hyperglycemia in dogs when given at 1 g/kg but not at 8 mg/kg, although postprandial energy expenditure is increased at the lower dose.

Chemical properties

White Solid

The Uses of D-MANNOHEPTULOSE

Mannoheptulose occurs naturally in avocado fruit.

The Uses of D-MANNOHEPTULOSE

Mannoheptulose occurs naturally in avocado fruit. It is used for normalizing insulin levels and reducing weight.

What are the applications of Application

D-Mannoheptulose is a hexokinase inhibitor that blocks glucose phosphorylation

Definition

ChEBI: D-keto-manno-heptulose is the open chain form of D-manno-heptulose.

Properties of D-MANNOHEPTULOSE

Melting point: 148-150°C
Boiling point: 628.0±55.0 °C(Predicted)
alpha  D20 +29° (c = 2 in H2O)
Density  1.645±0.06 g/cm3(Predicted)
storage temp.  Refrigerator
solubility  Methanol (Slightly), Water (Slightly)
pka 11.86±0.20(Predicted)
form  Solid
color  White to Off-White
Merck  13,4686
BRN  1726433
EPA Substance Registry System D-manno-2-Heptulose (3615-44-9)

Safety information for D-MANNOHEPTULOSE

Computed Descriptors for D-MANNOHEPTULOSE

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