D-MANNOHEPTULOSE

Synonym(s):D-Manno-2-heptulose

CAS NO.：3615-44-9
Empirical Formula: C7H14O7
Molecular Weight: 210.18
MDL number: MFCD00037814
EINECS: 222-795-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-28 13:53:23

What is D-MANNOHEPTULOSE?

Description

D-Glucose is phosphorylated by glucokinase and three tissue-specific hexokinases to produce glucose-6-phosphate in humans. D-Mannoheptulose is a heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (K_i = 0.25 mM). It blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells. D-Mannoheptulose prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein. By blocking glucose phosphorylation, D-mannoheptulose causes transient hyperglycemia in dogs when given at 1 g/kg but not at 8 mg/kg, although postprandial energy expenditure is increased at the lower dose.

Chemical properties

White Solid

The Uses of D-MANNOHEPTULOSE

Mannoheptulose occurs naturally in avocado fruit.

The Uses of D-MANNOHEPTULOSE

Mannoheptulose occurs naturally in avocado fruit. It is used for normalizing insulin levels and reducing weight.

What are the applications of Application

D-Mannoheptulose is a hexokinase inhibitor that blocks glucose phosphorylation

Definition

ChEBI: D-keto-manno-heptulose is the open chain form of D-manno-heptulose.

Properties of D-MANNOHEPTULOSE

Melting point:	148-150°C
Boiling point:	628.0±55.0 °C(Predicted)
alpha	D20 +29° (c = 2 in H2O)
Density	1.645±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	Methanol (Slightly), Water (Slightly)
pka	11.86±0.20(Predicted)
form	Solid
color	White to Off-White
Merck	13,4686
BRN	1726433
EPA Substance Registry System	D-manno-2-Heptulose (3615-44-9)