D-gamma-Tocopherol
Synonym(s):(+)-γ-Tocopherol;(R,R,R)-γ-Tocopherol;7,8-Dimethyltocol;gamma-Tocopherol
- CAS NO.:54-28-4
- Empirical Formula: C28H48O2
- Molecular Weight: 416.68
- MDL number: MFCD00066529
- EINECS: 200-201-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:07:02
What is D-gamma-Tocopherol?
Chemical properties
clear light brown viscous liquid
The Uses of D-gamma-Tocopherol
One of the naturally occurring forms of Vitamin E. Most abundant Tocopherol in soybean and corn oils.
The Uses of D-gamma-Tocopherol
(+)-γ-Tocopherol has been used:
- as reference material for the quantification of γ-tocopherol in the oil sample using high performance liquid chromatography with diode array detector (HPLC/DAD)(192}
- as a component of diet to feed vitamin-E-depleted rats to study its effects
- as an additive in the feed to study its effects in reducing dietary induced oxidative stress in vivo and improving meat lipid stability in broilers
The Uses of D-gamma-Tocopherol
This Certified Spiking Solution? is suitable for use as a starting material in the preparation of linearity standards, calibrators, and controls in a variety of testing applications from diagnostic testing of Vitamin E deficiency by LC-MS/MS or HPLC to quality control testing of tocopherol-based dietary supplements or pharmaceutical preparations.
What are the applications of Application
γ-Tocopherol is a naturally occurring tocopherol
Definition
ChEBI: Gamma-tocopherol is a tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils. It has a role as a plant metabolite, a food antioxidant and an algal metabolite. It is a vitamin E and a tocopherol.
General Description
A lipid soluble form of Vitamin E, gamma-Tocopherol is important to human health as an antioxidant and food additive. Vitamin E deficiency, often the result of poor nutrition or low absorption of dietary fat, is monitored in patient serum samples by LC-MS/MS or HPLC.
Biochem/physiol Actions
Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble antioxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.
Purification Methods
-Tocopherol is purified by distillation at high vacuum and stored in dark ampoules under N2. UV: max at 298nm (A1cm 1% 92.8). It is insoluble in H2O but soluble in organic solvents. The allophanate (used for separating it from its isomers) has m 136-138o, [] D 18 +3.4o (CHCl3). [Baxter et al. J Am Chem Soc 65 918 1943, Emerson et al. Science 83 421 1936, J Biol Chem 113 319 1936, Beilstein 17/4 V 158.]
Properties of D-gamma-Tocopherol
Boiling point: | 200 °C (0.1 mmHg) |
alpha | 30 º (C=2.0 IN ISOOCTANE 25 ºC) |
Density | 0.9882 (rough estimate) |
refractive index | n |
Flash point: | 9℃ |
storage temp. | -20°C |
solubility | Chloroform (Sparingly), Ethanol (Slightly), Methanol (Sparingly) |
form | Viscous Liquid |
pka | 11.05±0.40(Predicted) |
color | Clear light brown |
Merck | 13,9573 |
BRN | 93072 |
Stability: | Light Sensitive |
CAS DataBase Reference | 54-28-4(CAS DataBase Reference) |
EPA Substance Registry System | D-.gamma.-Tocopherol (54-28-4) |
Safety information for D-gamma-Tocopherol
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for D-gamma-Tocopherol
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