D-(-)-Asparagine monohydrate

Synonym(s):(R)-(-)-2-Aminosuccinamic acid;(R)-2-Aminosuccinic acid 4-amide;(D)-Aspartic acid 4-amide

CAS NO.：2058-58-4
Empirical Formula: C4H8N2O3
Molecular Weight: 132.12
MDL number: MFCD00149558
EINECS: 218-163-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is D-(-)-Asparagine monohydrate?

Chemical properties

crystalline powder

The Uses of D-(-)-Asparagine monohydrate

D-Asparagine is an isomer of L-Asparagine (A790005) and is used by bacteria (such as Saccharomyces cerevisiae) as a sole nitrogen source for replication. L-Asparagine is also a competitive inhibitor of staphylococcal L-asparaginase and is used as a reagent to synthesize peptide antibiotics.

Definition

ChEBI: An optically active form of asparagine having D-configuration.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 35, p. 2994, 1987 DOI: 10.1248/cpb.35.2994

Properties of D-(-)-Asparagine monohydrate

Melting point:	280 °C (dec.) (lit.)
Boiling point:	438.0±40.0 °C(Predicted)
alpha	-35 º (c=5, 5M HCl)
Density	1.404±0.06 g/cm3(Predicted)
storage temp.	Store at 0-5°C
solubility	Aqueous Acid (Sparingly), Water (Slightly, Sonicated)
form	Solid
pka	2.17(at 20℃)
color	White to Off-White
optical activity	[α]20/D 35°, c = 5 in 5 M HCl
Merck	13,842
BRN	1723526
Stability:	Hygroscopic
CAS DataBase Reference	2058-58-4(CAS DataBase Reference)

Safety information for D-(-)-Asparagine monohydrate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.